Short-term facilitation effects elicited by cortical priming through theta burst stimulation and functional electrical stimulation of upper-limb muscles
Short-term facilitation effects elicited by cortical priming through theta burst stimulation and functional electrical stimulation of upper-limb muscles
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通过上肢肌肉的θ爆发刺激和功能性电刺激皮质启动引起的短期促进效应
DOI：
10.1007/s00221-022-06353-3
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发表时间：
2022
影响因子：
2
通讯作者：
Nakazawa Kimitaka
中科院分区：
文献类型：
--
作者：
Cao Na;Sasaki Atsushi;Yuasa Akiko;Popovic Milos R.;Milosevic Matija;Nakazawa Kimitaka
非侵入性电刺激(TBS)间歇应用(ITBS)或连续应用(CTBS)可引起中枢神经系统易感性或抑制性改变。相反，神经肌肉电刺激(NMES)可以激活肌肉发出感觉抽射，这也是众所周知的影响中枢神经系统的兴奋性。我们研究了皮层ITBS(促进性)或CTBS(抑制性)启动是否会影响随后NMES诱导的皮质脊髓兴奋性。共测试了6种干预措施，每种干预措施有11名健全参与者：先进行皮质刺激，然后进行非脑电刺激(ITBS + 和CTBS + NMES)，仅进行非脑电刺激(iTBSsham+ NMES和cTB Ssham+ NMES)，以及只进行皮质刺激(ITBS + Rest和CTBS + Rest)。在ITBS或CTBS预充后，用NMES间歇性激活右侧桡伸肌群10min(S开启5次/S关闭5次)。比较每次干预30min前后单脉冲经颅磁刺激运动诱发电位(MEP)和最大运动反应(MMAX)的变化。结果表明，联合促进型 + -NMES干预可诱导出更强的MEP易化作用，并在干预后至少持续30min，而单独干预均不能产生效果。我们的结论是，易化性ITBS启动可以使中枢神经系统对NMES引起的变化更敏感，通过感觉招募来增强皮质脊髓可塑性的易化，而CTBS抑制性启动的效果尚不确定。
Non-invasive theta burst stimulation (TBS) can elicit facilitatory or inhibitory changes in the central nervous system when applied intermittently (iTBS) or continuously (cTBS). Conversely, neuromuscular electrical stimulation (NMES) can activate the muscles to send a sensory volley, which is also known to affect the excitability of the central nervous system. We investigated whether cortical iTBS (facilitatory) or cTBS (inhibitory) priming can affect subsequent NMES-induced corticospinal excitability. A total of six interventions were tested, each with 11 able-bodied participants: cortical priming followed by NMES (iTBS + NMES and cTBS + NMES), NMES only (iTBSsham+ NMES and cTBSsham+ NMES), and cortical priming only (iTBS + rest and cTBS + rest). After iTBS or cTBS priming, NMES was used to activate right extensor capri radialis (ECR) muscle intermittently for 10 min (5 s ON/5 s OFF). Single-pulse transcranial magnetic stimulation motor evoked potentials (MEPs) and maximum motor response (Mmax) elicited by radial nerve stimulation were compared before and after each intervention for 30 min. Our results showed that associative facilitatory iTBS + NMES intervention elicited greater MEP facilitation that lasted for at least 30 min after the intervention, while none of the interventions alone were effective to produce effects. We conclude that facilitatory iTBS priming can make the central nervous system more susceptible to changes elicited by NMES through sensory recruitment to enhance facilitation of corticospinal plasticity, while cTBS inhibitory priming efficacy could not be confirmed.
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神经肌肉电刺激踝跖屈肌后短期抑制下肢多块肌肉的脊髓反射
影响因子：
2
作者：
Milosevic Matija;Masugi Yohei;Obata Hiroki;Sasaki Atsushi;Popovic Milos R.;Nakazawa Kimitaka
通讯作者：
Nakazawa Kimitaka
影响因子：
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作者：
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通讯作者：
Grefkes, Christian
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作者：
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通讯作者：
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作者：
Yoshiyuki Suzuki;Naotsugu Kaneko;Atsushi Sasaki;F. Tanaka;K. Nakazawa;T. Nomura;Matija Milosevic
通讯作者：
Yoshiyuki Suzuki;Naotsugu Kaneko;Atsushi Sasaki;F. Tanaka;K. Nakazawa;T. Nomura;Matija Milosevic
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影响因子：
2.5
作者：
Majid,DSAdnan;Lewis,Christina;Aron,AdamR
通讯作者：
Aron,AdamR