Low hair cortisol concentration and emerging attention‐deficit/hyperactivity symptoms in preschool age
Low hair cortisol concentration and emerging attention‐deficit/hyperactivity symptoms in preschool age
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学龄前儿童头发皮质醇浓度低和出现注意力缺陷/多动症状
DOI：
10.1002/dev.21627
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发表时间：
2018
影响因子：
2.2
通讯作者：
Pauli-Pott
中科院分区：
文献类型：
--
作者：
Schloß;Müller;Becker;Skoluda;U. M. ;Pauli-Pott
先前的研究表明，注意力缺陷/多动障碍（ADHD）或外部症状儿童的HPA轴活动减退。我们分析了长期HPA轴活动与学龄前ADHD症状增加之间的预测关联。样本包括n = 125名4岁儿童及其家人（包括n = 64名ADHD症状加重的儿童）。ADHD症状通过与母亲的结构化临床访谈以及家长和教师报告问卷进行评估。通过毛发皮质醇浓度（HCC）（3个月内）评估长期HPA轴活性。在控制了潜在的混杂因素后，低HCC预测了4至5岁之间ADHD症状的增加。对性别效应的探索表明，在男孩中，横截面和预测关联是显著的，但在女孩中则不然。因此，低HCC可能被视为ADHD可能与性别相关的发育途径的早期标志物。
Previous research demonstrated hypoactivity of the HPA axis in children with attention‐deficit/hyperactivity disorder (ADHD) or externalizing symptoms. We analyzed the predictive association between the long‐term HPA axis activity and increasing symptoms of ADHD in the preschool period. The sample consisted ofn= 125 4‐year‐old children and their families (includingn= 64 children with elevated ADHD symptoms). ADHD symptoms were assessed by a structured clinical interview with the mother and by parent‐ and teacher‐report questionnaires. The long‐term HPA axis activity was assessed by the hair cortisol concentration (HCC) (over a 3‐month period). After controlling for potential confounders, low HCC predicted an increase in ADHD symptoms between the age of 4 and 5 years. Exploration of gender effects revealed that cross‐sectional and predictive associations were significant in boys but not in girls. Low HCC might thus be regarded as an early marker of a possibly gender‐related developmental pathway to ADHD.
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影响因子：
3.7
作者：
Pauli-Pott;Schloß;Skoluda;N.. Nater;U. M. ;Becker
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
10.1016/j.jaac.2016.04.004
发表时间：
2016-06
影响因子：
13.3
作者：
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通讯作者：
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