Hair cortisol concentration in preschoolers with attention-deficit/hyperactivity symptoms—Roles of gender and family adversity
Hair cortisol concentration in preschoolers with attention-deficit/hyperactivity symptoms—Roles of gender and family adversity
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患有注意力缺陷/多动症状的学龄前儿童头发皮质醇浓度——性别和家庭逆境的作用
DOI：
10.1016/j.psyneuen.2017.09.002
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发表时间：
2017
影响因子：
3.7
通讯作者：
Becker
中科院分区：
文献类型：
--
作者：
Pauli-Pott;Schloß;Skoluda;N.. Nater;U. M. ;Becker
目的先前关于下丘脑-垂体-肾上腺轴(HPAA)活性与ADHD之间关系的研究结果不一致，尤其是在较小的儿童中。这可能是由于疾病的异质性，使得变量的调节效应成为可能，这些变量限制了更多同质的亚群。有迹象表明，儿童性别和家庭逆境对这种联系起到了调节作用。此外，在获取较小儿童的长期基础HPAA活性方面的困难可能是导致不一致的原因之一。因此，我们分析了性别和家庭逆境的调节作用，同时使用头发皮质醇浓度(HCC)来评估综合长期HPA。方法以社区为基础的样本包括122名4-5岁学龄前儿童(71名ADHD症状筛查阳性)。ADHD症状通过临床家长访谈和家长和教师问卷进行评估。对头皮毛发最近端3 cm处的肝细胞癌进行发光免疫分析。结果分层线性回归分析显示ADHD症状组与性别之间存在交互作用(P<0.05)，提示ADHD症状升高的男童肝细胞癌发生率较低。进一步的探索性分析发现，这种交互作用在家庭逆境条件下最为显著。在控制了对立、焦虑和抑郁症状后，结果是成立的。结论低肝癌可能提示ADHD症状升高的男孩的一种特殊的致病机制。这种机制可能还包括暴露在家庭逆境中。然而，在得出最终结论之前，需要对结果进行交叉验证。
ObjectivePrevious studies on the association between hypothalamic-pituitary-adrenal axis (HPAA) activity and ADHD yielded inconsistent findings, particularly in younger children. This might be due to the heterogeneity of the disorder, making moderator effects of variables probable, which circumscribe more homogenous subgroups. There have been indications of moderator effects on this association by gender of child and exposure to family adversity. Moreover, difficulties in capturing long-term basal HPAA activity in younger children might have contributed to the inconsistencies. We therefore analyzed moderator effects of gender and family adversity while using the hair cortisol concentration (HCC) to assess integrated long-term HPAA.MethodsThe community-based sample consisted of 122 4–5-year-old preschoolers (71 screened positive for elevated ADHD symptoms). ADHD symptoms were measured by a clinical parent interview and parent and teacher questionnaires. HCC in the most proximal 3-cm scalp hair segment was analyzed using luminescence immunoassay. An extended family adversity index was used.ResultsHierarchical linear regression analyses yielded an interaction effect (p < .05) between ADHD symptom groups and gender on HCC, indicating a low HCC in boys with elevated ADHD symptoms. Further exploratory analyses revealed that this interaction effect was most pronounced under the condition of family adversity. The results held after controlling for oppositional, anxiety, and depressive symptoms.ConclusionLow HCC might indicate a specific pathogenic mechanism in boys with elevated ADHD symptoms. This mechanism might further involve an exposure to family adversity. However, the results need to be cross-validated before definitive conclusions can be drawn.
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DOI：
10.1111/jcpp.12337
发表时间：
2015-06
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Arnett AB;Pennington BF;Willcutt EG;DeFries JC;Olson RK
通讯作者：
Olson RK
社会风险因素和 HPA 轴失调在预测五六岁儿童情绪症状中的相互作用。
影响因子：
4.8
作者：
K. von Klitzing;S. Perren;A. Klein;S. Stadelmann;L. White;Maureen Groeben;E. Holsboer;S. Brand;M. Hatzinger
通讯作者：
M. Hatzinger
虐待后头发皮质醇减少介导童年中期和青春期的外化症状
影响因子：
7.6
作者：
von Klitzing;Sierau;Michel;A. M.. . . Stalder
通讯作者：
A. M.. . . Stalder
注意力缺陷多动障碍的家庭环境危险因素。
影响因子：
--
作者：
Biederman,J;Milberger,S;Faraone,SV;Kiely,K;Guite,J;Mick,E;Ablon,S;Warburton,R;Reed,E
通讯作者：
Reed,E
影响因子：
3.7
作者：
Saridjan, Nathalie S.;Velders, Fleur P.;Tiemeier, Henning
通讯作者：
Tiemeier, Henning