Hormonal aspects of epilepsy.
Hormonal aspects of epilepsy.
复制标题
DOI：
10.1016/j.ncl.2009.08.005
复制
发表时间：
2009-11
影响因子：
2.4
通讯作者：
Pennell, Page B.
中科院分区：
文献类型：
--
作者：
Pennell, Page B.
激素，癫痫和用于治疗癫痫的药物之间的相互作用是复杂的，具有三向相互作用，以各种方式影响男性和女性。基线内分泌状态异常在癫痫患者中更常见，并且最常描述为性类固醇激素轴。常见症状包括性功能障碍、生育能力下降、过早绝经和多囊卵巢综合征。抗癫痫药物和激素具有双向相互作用，激素避孕药与某些AED的疗效降低，其他AED与激素避孕药的浓度和疗效降低。内源性激素可以影响癫痫发作的严重程度和频率，导致月经性癫痫。然而，这些知识可用于制定激素策略，以改善癫痫患者的癫痫发作控制。
The interactions between hormones, epilepsy, and the medications used to treat epilepsy are complex, with tridirectional interactions which affect both men and women in various ways. Abnormalities of baseline endocrine status occur more commonly in people with epilepsy, and are most often described for the sex steroid hormone axis. Common symptoms include sexual dysfunction, decreased fertility, premature menopause, and polycystic ovarian syndrome. Antiepileptic drugs and hormones have a bidirectional interaction, with a decrease in the efficacy of hormonal contraceptive agents with some AEDs and a decrease in the concentration and efficacy of other AEDs with hormonal contraceptives. Endogenous hormones can influence seizure severity and frequency, resulting in catamenial patterns of epilepsy. However, this knowledge can be used to develop hormonal strategies to improve seizure control in people with epilepsy.
登录
查看更多内容
影响因子：
5
作者：
Artama, M;Isojärvi, JIT;Auvinen, A
通讯作者：
Auvinen, A
影响因子：
11
作者：
COLLINS, WCJ;LANIGAN, O;CALLAGHAN, N
通讯作者：
CALLAGHAN, N
影响因子：
5.6
作者：
DUNCAN, S;READ, CL;BRODIE, MJ
通讯作者：
BRODIE, MJ
影响因子：
5.6
作者：
DANSKY, LV;ANDERMANN, E;ANDERMANN, F
通讯作者：
ANDERMANN, F
影响因子：
5.6
作者：
El-Khayat, Hamed A.;Soliman, Nancy A.;Shatla, Rania H.
通讯作者：
Shatla, Rania H.