Effect of surfactant and partial liquid ventilation treatment on gas exchange and lung mechanics in immature lambs: influence of gestational age.
Effect of surfactant and partial liquid ventilation treatment on gas exchange and lung mechanics in immature lambs: influence of gestational age.
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DOI：
10.1371/journal.pone.0056127
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Murgia X
中科院分区：
文献类型：
--
作者：
Rey-Santano C;Mielgo V;Gastiasoro E;Valls-i-Soler A;Murgia X
肺表面活性物质（SF）和部分液体通气（PLV）可改善新生儿RDS的气体交换和肺力学。然而，SF和PLV的影响与肺不成熟程度的变化尚未得到彻底探讨。实验新生儿呼吸生理学研究单位，克鲁塞斯大学医院。使用密封信封的前瞻性随机研究。36只早产羔羊通过剖腹手术暴露（胎龄125或133天）并插管。将导管置于颈静脉和颈动脉中。所有羔羊被分配到三个亚组中的一个：20 mL/Kg全氟化碳，并使用部分液体通气（PLV）、表面活性剂（Curosurf®，200 mg/kg）或（3）无肺部处理（对照组）进行3 h管理。测定心血管参数、血气和肺力学。在125天的妊娠羔羊，SF治疗部分改善气体交换和肺力学，而PLV产生显着的快速改善这些参数。在133日龄羔羊中，SF或PLV治疗取得了类似的良好反应。表面活性剂和PLV均不显著影响心血管参数。SF治疗反应在较大胎龄组中更有效，而PLV治疗的有效性不依赖于胎龄。
Surfactant (SF) and partial liquid ventilation (PLV) improve gas exchange and lung mechanics in neonatal RDS. However, variations in the effects of SF and PLV with degree of lung immaturity have not been thoroughly explored. Experimental Neonatal Respiratory Physiology Research Unit, Cruces University Hospital. Prospective, randomized study using sealed envelopes. 36 preterm lambs were exposed (at 125 or 133-days of gestational age) by laparotomy and intubated. Catheters were placed in the jugular vein and carotid artery. All the lambs were assigned to one of three subgroups given: 20 mL/Kg perfluorocarbon and managed with partial liquid ventilation (PLV), surfactant (Curosurf®, 200 mg/kg) or (3) no pulmonary treatment (Controls) for 3 h. Cardiovascular parameters, blood gases and pulmonary mechanics were measured. In 125-day gestation lambs, SF treatment partially improved gas exchange and lung mechanics, while PLV produced significant rapid improvements in these parameters. In 133-day lambs, treatments with SF or PLV achieved similarly good responses. Neither surfactant nor PLV significantly affected the cardiovascular parameters. SF therapy response was more effective in the older gestational age group whereas the effectiveness of PLV therapy was not gestational age dependent.
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DOI：
10.1164/rccm.200508-1196oc
发表时间：
2006-04-15
影响因子：
24.7
作者：
Kacmarek, RM;Wiedemann, HP;Slutsky, AS
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影响因子：
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DOI：
10.1152/ajplung.00294.2010
发表时间：
2011-02-01
影响因子：
4.9
作者：
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