Scaffold design for bone regeneration.
Scaffold design for bone regeneration.
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DOI：
10.1166/jnn.2014.9127
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发表时间：
2014-01
影响因子：
--
通讯作者：
Ramirez-Vick JE
中科院分区：
文献类型：
--
作者：
Polo-Corrales L;Latorre-Esteves M;Ramirez-Vick JE
使用骨移植物是治疗骨折或替换和再生丢失骨的标准方法，正如全球范围内进行的大量骨移植手术所证明的那样。其中最常见的是自体移植，然而，其使用可导致并发症，如疼痛、感染、瘢痕形成、失血和供体部位发病。另一种方法是同种异体移植，但它们缺乏自体移植的骨活性，并有携带感染因子或免疫排斥反应的风险。其他方法，如骨移植替代物，集中于通过掺入骨祖细胞和生长因子来刺激细胞来提高骨移植物或其他支架的功效。理想的骨移植物或支架应由模仿天然骨ECM的结构和性质的生物材料制成，包括骨祖细胞并提供天然骨中发现的所有必要的环境提示。然而，到目前为止，创建在结构上、功能上和机械上与天然骨相当的活组织构建体一直是一个挑战。这篇综述的重点是在重建骨组织微环境的过程中，包括生物化学和生物物理学线索，这些支架作为骨移植替代品的演变。
The use of bone grafts is the standard to treat skeletal fractures, or to replace and regenerate lost bone, as demonstrated by the large number of bone graft procedures performed worldwide. The most common of these is the autograft, however, its use can lead to complications such as pain, infection, scarring, blood loss, and donor-site morbidity. The alternative is allografts, but they lack the osteoactive capacity of autografts and carry the risk of carrying infectious agents or immune rejection. Other approaches, such as the bone graft substitutes, have focused on improving the efficacy of bone grafts or other scaffolds by incorporating bone progenitor cells and growth factors to stimulate cells. An ideal bone graft or scaffold should be made of biomaterials that imitate the structure and properties of natural bone ECM, include osteoprogenitor cells and provide all the necessary environmental cues found in natural bone. However, creating living tissue constructs that are structurally, functionally and mechanically comparable to the natural bone has been a challenge so far. This focus of this review is on the evolution of these scaffolds as bone graft substitutes in the process of recreating the bone tissue microenvironment, including biochemical and biophysical cues.
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