Post-weaning stroking stimuli induce affiliative behavior toward humans and influence brain activity in female rats.
Post-weaning stroking stimuli induce affiliative behavior toward humans and influence brain activity in female rats.
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DOI：
10.1038/s41598-021-83314-w
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发表时间：
2021-02-15
影响因子：
4.6
通讯作者：
Onaka T
中科院分区：
文献类型：
--
作者：
Okabe S;Takayanagi Y;Yoshida M;Onaka T
温柔的触摸有助于亲密互动。我们研究了轻柔的抚摸对雌性大鼠对人类的依恋行为发展的影响，并探索性地检查了受抚摸影响的大脑活动区域。断奶后反复接受抚摸刺激的大鼠发出50千赫的叫声，这是一种积极情绪指数，并表现出对实验者的附属行为。大鼠中风后下丘脑室旁催产素神经元被激活。断奶后被抚摸的大鼠中隔下丘脑核（SHy）对抚摸刺激的反应活性明显低于未被抚摸的对照组。下丘脑区域的神经活动与50 khz的呼叫次数呈负相关。这些发现表明，断奶后的抚摸可能通过激活催产素神经元和抑制下丘脑神经元的活动，诱导了雌性大鼠和人类之间的亲缘关系。
Gentle touch contributes to affiliative interactions. We investigated the effects of gentle stroking in female rats on the development of affiliative behaviors toward humans and we exploratively examined brain regions in which activity was influenced by stroking. Rats that had received stroking stimuli repeatedly after weaning emitted 50-kHz calls, an index of positive emotion, and showed affiliative behaviors toward the experimenter. Hypothalamic paraventricular oxytocin neurons were activated in the rats after stroking. The septohypothalamic nucleus (SHy) in the post-weaningly stroked rats showed decreased activity in response to stroking stimuli compared with that in the non-stroked control group. There were negative correlations of neural activity in hypothalamic regions including the SHy with the number of 50-kHz calls. These findings revealed that post-weaning stroking induces an affiliative relationship between female rats and humans, possibly via activation of oxytocin neurons and suppression of the activity of hypothalamic neurons.
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