Racial differences in the human endogenous circadian period.
Racial differences in the human endogenous circadian period.
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DOI：
10.1371/journal.pone.0006014
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发表时间：
2009-06-30
期刊：
影响因子：
3.7
通讯作者：
Eastman CI
中科院分区：
文献类型：
--
作者：
Smith MR;Burgess HJ;Fogg LF;Eastman CI
人体生物钟（tau）内源周期的长度略大于24小时。 tau 蛋白存在个体差异，会影响光/暗 (LD) 循环夹带的相位角，从而导致早晚现象。我们最近报道，生活在超日 LD 周期的受试者中测量的 tau 蛋白平均为 24.2 小时，并且与使用不同实验方法测量的 tau 蛋白相似。在这里，我们报告了 tau 蛋白的种族差异。受试者以超日 LD 周期（1.5 小时睡眠，2.5 小时清醒）生活 3 天。在超日之前和之后进行昼夜节律阶段评估，以确定由 tau 引起的昼夜节律阶段的变化。非裔美国人受试者的 tau 蛋白明显短于其他种族受试者。我们还在之前的昼夜节律相位提前和相位延迟研究中测试了种族差异。在阶段推进研究中，受试者接受了为期 4 天的逐渐推进的睡眠时间表，并在每天早上醒来时接受明亮的光脉冲。在相位延迟研究中，受试者接受了为期 4 天的逐渐延迟的睡眠时间表，并在睡前接受夜间光脉冲。相对于白种人受试者，非裔美国人受试者具有较大的相位超前和较小的相位延迟。 tau 蛋白和昼夜节律相移的种族差异对于理解个体之间的正常相位差、开发时差和轮班工作问题的解决方案以及基于昼夜节律的睡眠障碍（例如提前和延迟睡眠相位障碍）的诊断和治疗具有重要意义。
The length of the endogenous period of the human circadian clock (tau) is slightly greater than 24 hours. There are individual differences in tau, which influence the phase angle of entrainment to the light/dark (LD) cycle, and in doing so contribute to morningness-eveningness. We have recently reported that tau measured in subjects living on an ultradian LD cycle averaged 24.2 hours, and is similar to tau measured using different experimental methods. Here we report racial differences in tau. Subjects lived on an ultradian LD cycle (1.5 hours sleep, 2.5 hours wake) for 3 days. Circadian phase assessments were conducted before and after the ultradian days to determine the change in circadian phase, which was attributed to tau. African American subjects had a significantly shorter tau than subjects of other races. We also tested for racial differences in our previous circadian phase advancing and phase delaying studies. In the phase advancing study, subjects underwent 4 days of a gradually advancing sleep schedule combined with a bright light pulse upon awakening each morning. In the phase delaying study, subjects underwent 4 days of a gradually delaying sleep schedule combined with evening light pulses before bedtime. African American subjects had larger phase advances and smaller phase delays, relative to Caucasian subjects. The racial differences in tau and circadian phase shifting have important implications for understanding normal phase differences between individuals, for developing solutions to the problems of jet lag and shift work, and for the diagnosis and treatment of circadian rhythm based sleep disorders such as advanced and delayed sleep phase disorder.
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影响因子：
4.8
作者：
Rao, U;Poland, RE;Lim, KM
通讯作者：
Lim, KM
影响因子：
4.4
作者：
Hiddinga, AE;Beersma, DGM;VandenHoofdakker, RH
通讯作者：
VandenHoofdakker, RH
影响因子：
2.8
作者：
Smith MR;Eastman CI
通讯作者：
Eastman CI
影响因子：
4.8
作者：
Smith, Mark R.;Revell, Victoria L.;Eastman, Charmane I.
通讯作者：
Eastman, Charmane I.
DOI：
10.1007/bf01417856
发表时间：
1976-01-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY
影响因子：
--
作者：
PITTENDRIGH, CS;DAAN, S
通讯作者：
DAAN, S