Omega-3 fatty acids ameliorate cognitive dysfunction in schizophrenia patients with metabolic syndrome
Omega-3 fatty acids ameliorate cognitive dysfunction in schizophrenia patients with metabolic syndrome
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Omega-3 脂肪酸可改善代谢综合征精神分裂症患者的认知功能障碍
DOI：
10.1016/j.bbi.2020.04.034
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发表时间：
2020-04
期刊：
影响因子：
--
通讯作者：
Zhang Chen
中科院分区：
文献类型：
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作者：
Tang Wei;Wang Yewei;Xu Feikang;Fan Weixing;Zhang Yaoyao;Fan Kaili;Wang Weiping;Zhang Yi;Zhang Chen
我们以前的研究表明，代谢异常降低了脑源性神经营养因子（BDNF）的水平，并恶化了精神分裂症患者的认知能力。炎症可能在这一过程中发挥关键作用。Omega-3脂肪酸已被证明可以改善炎症。因此，我们假设ω-3脂肪酸可能在提高BDNF水平和改善精神分裂症伴代谢综合征（MetS）患者的认知功能方面具有价值。我们招募了80例长期接受奥氮平单药治疗的精神分裂症和代谢综合征患者。采用酶联免疫吸附法测定血浆C反应蛋白（CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平。患者被随机分配到OMG-3组（n = 40）或安慰剂组（n = 40）。在同意参加研究的80例患者中，72例完成了这项为期12周的RCT。主要结局是临床特征和BDNF、CRP、IL-6和TNF-α水平从基线到12周的变化。当患者完成这项研究时，在RBANS评估中，omega-3脂肪酸治疗与增强延迟记忆因子之间存在显著相关性（F组×时间= 6.82;df= 1，66;P= 0.01）。沿着认知能力的提高，omega-3脂肪酸增强了BDNF（F组×时间= 4.93;df= 1，66;P= 0.03）和CRP降低（F组×时间= 17.11;df= 1，66;P< 0.01），IL-6（F组×时间= 9.71;df= 1，66;P< 0.004）和TNF-α（F组×时间= 6.71;df= 1，66;P= 0.012）水平。BDNF水平的变化与TNF-α水平的变化呈负相关（r=-0.37，P = 0.03），而与CRP和IL-6水平的变化无相关性。我们的研究结果提供了提示性证据，表明ω-3脂肪酸对MetS患者的认知功能具有有益作用，这与增强的BDNF水平有关。
Our previous study showed that metabolic abnormalities reduced the levels of brain-derived neurotrophic factor (BDNF) and deteriorated cognitive performance in patients with schizophrenia. Inflammation may play a key role in this process. Omega-3 fatty acids have been documented to ameliorate inflammation. Therefore, we hypothesized that omega-3 fatty acids may be of value in enhancing BDNF levels and improving cognitive function in patients with schizophrenia with metabolic syndrome (MetS). We recruited 80 patients with both schizophrenia and MetS who received long-term olanzapine monotherapy. The enzyme-linked immunosorbent assay was used to measure the plasma levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). The patients were randomly assigned to the OMG-3 group (n = 40) or the placebo group (n = 40). Of the 80 patients who consented to the study, 72 completed this 12-week RCT. The primary outcome was the changes from baseline to 12 weeks in clinical characteristics and the levels of BDNF, CRP, IL-6 and TNF-α. There was a significant correlation between omega-3 fatty acid treatment and enhanced delayed memory factor in the RBANS assessment (Fgroup×time= 6.82;df= 1, 66;P= 0.01) when the patients completed this study. Along with cognitive improvement, omega-3 fatty acids enhanced BDNF (Fgroup×time= 4.93;df= 1, 66;P= 0.03) and reduced CRP (Fgroup×time= 17.11;df= 1, 66;P< 0.01), IL-6 (Fgroup×time= 9.71;df= 1, 66;P< 0.004) and TNF-α (Fgroup×time= 6.71;df= 1, 66;P= 0.012) levels after 12 weeks of treatment. The changes in BDNF levels are negatively correlated with the changes in TNF-α levels (r= −0.37,P= 0.03) but not with the changes in CRP and IL-6 levels. Our findings provide suggestive evidence that omega-3 fatty acids have beneficial effects on cognitive function in patients with MetS, which is paralleled by enhanced BDNF levels.
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作者：
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通讯作者：
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omega-3 脂肪酸对精神分裂症患者代谢综合征的影响：一项为期 12 周的随机安慰剂对照试验
影响因子：
3.4
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Xu Feikang;Fan Weixing;Wang Weiping;Tang Wei;Yang Fuyin;Zhang Yi;Cai Jun;Song Lisheng;Zhang Chen
通讯作者：
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