Impacts of event-specific air quality improvements on total hospital admissions and reduced systemic inflammation in COPD patients
Impacts of event-specific air quality improvements on total hospital admissions and reduced systemic inflammation in COPD patients
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特定事件的空气质量改善对 COPD 患者住院总人数和减少全身炎症的影响
DOI：
10.1371/journal.pone.0208687
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发表时间：
2019-03
期刊：
影响因子：
3.7
通讯作者：
Lu Wenju
中科院分区：
文献类型：
--
作者：
Zhang Zili;Wang Jian;Liu Fei;Yuan Liang;Yuan Jili;Chen Lianghua;Zhong Nanshan;Lu Wenju
有有限的证据表明，减少空气污染对住院人数的影响。潜在的生物学机制尚未完全了解。本研究探讨了缓解环境污染对慢性阻塞性肺疾病（COPD）患者入院率和炎症生物标志物水平的影响。将亚运会期间（2010年11月1日至12月21日）51天内的每日住院人数与基线年（2004-2009年和2011-2013年）的相同日历日期进行比较。在36名COPD患者参与者中进行了一项为期三年的队列研究。每日颗粒物（PM10）由基线期的65.86 μg/m3下降至亚运期间的62.63 μg/m3;每日NO2水平由51.33 μg/m3下降至42.63 μg/m3。在基线期和亚运会期间，非意外疾病的每日住院人数分别从116人减少到93人;呼吸系统疾病分别从20人减少到17人;心血管疾病分别从亚运会期间的11人减少到9人。在广州2010年剩余的几个月里，在对照城市亚运会期间，以及其他两种对照疾病，没有看到统计学上的显著下降。此外，我们发现CRP和纤维蛋白原从亚运会前到亚运会期间分别显著改善了-20.4%和-15.4%。对于CRP，我们发现NO2在亚运会后1 -3天显著增加，PM10在亚运会后1 -2天显著增加。纤维蛋白原也有类似的效果。这一发现为通过人类空气污染物干预来减少空气污染和改善公众健康的努力提供了支持。2010年亚运会期间空气污染的改善与COPD患者参与者中与全身炎症相关的生物标志物的减少相关。
There is limited evidence linking the impacts of reduced air pollution on hospital admissions. The potential biological mechanisms are still not completely understood. This study examined the effects of mitigated ambient pollution on hospital admissions and inflammatory biomarker levels in chronic obstructive pulmonary disease (COPD) COPD patients. Daily hospital admissions were compared over 51 days associated with the Asian Games period (Nov 1-Dec 21, 2010) with the identical calendar dates of baseline years (2004–2009 and 2011–2013). A three-year cohort study was conducted with 36 COPD patient participants. The daily particulate matter (PM10) decreased from 65.86 μg/m3 during the baseline period to 62.63 μg/m3 during the Asian Games period; the daily NO2 level decreased from 51.33 μg/m3 to 42.63 μg/m3. Between the baseline period and the Asian Games, daily hospital admissions from non-accidental diseases decreased from 116 to 93, respectively; respiratory diseases decreased from 20 to 17, respectively; and cardiovascular diseases decreased from 11 to 9 during the Asian Games period, respectively. No statistically significant reductions were seen in the remaining months of 2010 in Guangzhou, during the the Asian Games period in the control city, and two other control diseases. Furthermore, we identified significant improvement in CRP and fibrinogen by -20.4% and -15.4% from a pre-Asian game period to a during-Asian game period, respectively. For CRP, we found significant increases in NO2 at lag1-3 days after-Asian game period and significant increases in PM10 at lag1-2 days. Similar effects were also seen with fibrinogen. This discovery provides support for efforts to diminish air pollution and improve public health through human air pollutants intervention. Improved air pollution during the 2010 Asian games was correlated with decreases in biomarkers associated with systemic inflammation in COPD patient participants.
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影响因子：
10.4
作者：
Rückerl R;Greven S;Ljungman P;Aalto P;Antoniades C;Bellander T;Berglind N;Chrysohoou C;Forastiere F;Jacquemin B;von Klot S;Koenig W;Küchenhoff H;Lanki T;Pekkanen J;Perucci CA;Schneider A;Sunyer J;Peters A;AIRGENE Study Group
通讯作者：
AIRGENE Study Group
DOI：
10.1164/rccm.201010-1572oc
发表时间：
2011-05-01
影响因子：
24.7
作者：
Allen, Ryan W.;Carlsten, Chris;Brauer, Michael
通讯作者：
Brauer, Michael
DOI：
10.1164/rccm.200611-1627oc
发表时间：
2007-08-15
影响因子：
24.7
作者：
Chuang, Kai-Jen;Chan, Chang-Chuan;Tang, Chin-Sheng
通讯作者：
Tang, Chin-Sheng
影响因子：
10.4
作者：
Hoffmann B;Moebus S;Dragano N;Stang A;Möhlenkamp S;Schmermund A;Memmesheimer M;Bröcker-Preuss M;Mann K;Erbel R;Jöckel KH
通讯作者：
Jöckel KH
DOI：
10.2147/copd.s5098
发表时间：
2009
影响因子：
2.8
作者：
Ling SH;van Eeden SF
通讯作者：
van Eeden SF