Anogenital distance and penile length in infants with hypospadias or cryptorchidism: comparison with normative data.
Anogenital distance and penile length in infants with hypospadias or cryptorchidism: comparison with normative data.
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DOI：
10.1289/ehp.1307178
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发表时间：
2014-02
影响因子：
10.4
通讯作者：
Hughes IA
中科院分区：
文献类型：
--
作者：
Thankamony A;Lek N;Carroll D;Williams M;Dunger DB;Acerini CL;Ong KK;Hughes IA
动物肛门生殖器距离（AGD）是胎儿内分泌紊乱及相关睾丸发育不良综合征（TDS）的敏感生物标志物。然而，人类隐睾和尿道下裂婴儿的AGD，这是儿童时期TDS的潜在表现，并没有明确的描述。目的：我们的目的是比较男孩隐睾或尿道下裂的AGD与规范数据。方法：从第三中心招募孤立性隐睾（n = 71，年龄13.4±5.8个月）或尿道下裂（n = 81，年龄11.4±6.2个月）的男孩进行AGD和阴茎长度测量；将他们与来自出生队列的487名健康足月男孩进行比较，得出年龄特定标准差得分（SDS）。结果：隐睾患者比尿道下裂患者年龄大（p = 0.048）。尿道下裂男孩的平均AGD和阴茎长度SDS均短于健康男孩（p < 0.0001）。隐睾男孩的平均AGD和阴茎长度SDS值长于尿道下裂男孩（p < 0.01），短于健康男孩（p < 0.0001）。平均阴茎长度SDS随尿道下裂严重程度的增加而降低（p趋势= 0.078）。结论：在研究人群中，相对于来自纵向出生队列的规范数据，尿道下裂或隐睾男孩的AGD和阴茎长度减少。研究结果支持使用AGD作为定量生物标志物来检查产前暴露于内分泌干扰物对男性生殖道发育的影响。引用本文：Thankamony A， Lek N, Carroll D, Williams M, Dunger DB, Acerini CL, Ong KK, Hughes IA。2014. 尿道下裂或隐睾婴儿的肛门生殖器距离和阴茎长度：与规范数据的比较。环境卫生展望122:207-211；http://dx.doi.org/10.1289/ehp.1307178
Background: Anogenital distance (AGD) in animals is a sensitive biomarker of fetal endocrine disruption and the associated testicular dysgenesis syndrome (TDS). However, AGD in human infants with cryptorchidism and hypospadias, which are potential manifestations of TDS during childhood, is not clearly described. Objective: Our aim was to compare AGD in boys with cryptorchidism or hypospadias against normative data. Methods: Boys with isolated cryptorchidism (n = 71, age 13.4 ± 5.8 months) or hypospadias (n = 81, age 11.4 ± 6.2 months) were recruited from a tertiary center for measurement of AGD and penile length; they were compared with 487 healthy full-term boys from a birth cohort by deriving age-specific standard deviation scores (SDS). Results: Boys with cryptorchidism were older (p = 0.048) compared with boys with hypospadias. Boys with hypospadias had shorter mean AGD and penile length SDS than healthy boys (both p < 0.0001). Mean AGD and penile length SDS values in boys with cryptorchidism were longer than mean values in boys with hypospadias (both p < 0.01) and shorter than mean values in healthy boys (both p < 0.0001). Mean penile length SDS decreased as the severity of hypospadias increased (ptrend = 0.078). Conclusions: In the study population, AGD and penile length were reduced in boys with hypospadias or cryptorchidism relative to normative data derived from a longitudinal birth cohort. The findings support the use of AGD as a quantitative biomarker to examine the prenatal effects of exposure to endocrine disruptors on the development of the male reproductive tract. Citation: Thankamony A, Lek N, Carroll D, Williams M, Dunger DB, Acerini CL, Ong KK, Hughes IA. 2014. Anogenital distance and penile length in infants with hypospadias or cryptorchidism: comparison with normative data. Environ Health Perspect 122:207–211; http://dx.doi.org/10.1289/ehp.1307178
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影响因子：
5.2
作者：
Acerini, C. L.;Miles, H. L.;Hughes, I. A.
通讯作者：
Hughes, I. A.
影响因子：
1.8
作者：
Hosie, S;Loff, S;Waag, KL
通讯作者：
Waag, KL
影响因子：
5.1
作者：
CALLEGARI, C;EVERETT, S;BRASEL, JA
通讯作者：
BRASEL, JA
DOI：
10.1016/0007-1226(89)90140-9
发表时间：
1989-05-01
期刊：
BRITISH JOURNAL OF PLASTIC SURGERY
影响因子：
--
作者：
BRACKA, A
通讯作者：
BRACKA, A
影响因子：
10.4
作者：
Mendiola J;Stahlhut RW;Jørgensen N;Liu F;Swan SH
通讯作者：
Swan SH