Antimicrobial traits of tea- and cranberry-derived polyphenols against Streptococcus mutans.
Antimicrobial traits of tea- and cranberry-derived polyphenols against Streptococcus mutans.
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茶和蔓越莓衍生的多酚针对链球菌突变的抗菌特征。
DOI：
10.1159/000329181
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发表时间：
2011
期刊：
影响因子：
4.2
通讯作者：
Duarte S
中科院分区：
文献类型：
--
作者：
Yoo S;Murata RM;Duarte S
有超过750种细菌栖息在人类口腔中，但只有一小部分是由于引起牙菌斑相关疾病，如龋齿。变形链球菌被认为是主要的致龋因子，并且关于使生物体成为病原体的特定毒力因子有大量的知识。与目前使用的非特异性机械斑块清除或广谱抗菌药物的应用相反，人们对替代性、靶向特异性治疗方案的兴趣越来越大。饮食对口腔健康的影响是不可否认的，这在消费大量富含多酚的食物或饮料的人群中直接观察到。这些人群的龋齿发病率较低，整体口腔健康状况较好。茶树（Camellia sinensis），各种形式的茶的来源植物，以及大果越桔（Vaccinium macrocarpon）（美国蔓越莓果实）因其在人类饮食中的流行以及其独特的多酚成分而受到关注。这些植物的生物活性成分已被证明具有有效的酶抑制特性，而不会杀菌，这是开发不会导致微生物产生耐药性的疗法的重要关键品质。本综述的目的是考虑已经调查了茶，蔓越莓和其他选择的植物衍生物作为替代治疗剂对变形链球菌的潜在基础的可行性研究，并评估其当前和未来的临床意义。
There are over 750 species of bacteria that inhabit the human oral cavity, but only a small fraction of those are attributed to causing plaque-related diseases such as caries. Streptococcus mutans is accepted as the main cariogenic agent and there is substantial knowledge regarding the specific virulence factors that render the organism a pathogen. There has been rising interest in alternative, target-specific treatment options as opposed to nonspecific mechanical plaque removal or application of broad-spectrum antibacterials that are currently in use. The impact of diet on oral health is undeniable, and this is directly observable in populations that consume high quantities of polyphenol-rich foods or beverages. Such populations have low caries incidence and better overall oral health. Camellia sinensis, the plant from which various forms of tea are derived, and Vaccinium macrocarpon (American cranberry fruit) have received notable attention both for their prevalence in the human diet as well as for their unique composition of polyphenols. The biologically active constituents of these plants have demonstrated potent enzyme-inhibitory properties without being bactericidal, a key quality that is important in developing therapies that will not cause microorganisms to develop resistance. The aim of this review is to consider studies that have investigated the feasibility of tea, cranberry, and other select plant derivatives as a potential basis for alternative therapeutic agents against Streptococcus mutans and to evaluate their current and future clinical relevance.
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影响因子：
4.9
作者：
Koo, H;Rosalen, PL;Bowen, WH
通讯作者：
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影响因子：
120.7
作者：
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7.6
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4.2
作者：
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作者：
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