Natural killer cells: multifaceted players with key roles in hepatitis C immunity.
Natural killer cells: multifaceted players with key roles in hepatitis C immunity.
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DOI：
10.1111/imr.12090
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发表时间：
2013-09
影响因子：
8.7
通讯作者：
Rosen HR
中科院分区：
文献类型：
--
作者：
Golden-Mason L;Rosen HR
自然杀伤细胞（NK）参与丙型肝炎病毒（HCV）感染的每个阶段，从保护免受HCV感染和急性期的消退到治疗诱导的清除。除了它们的直接抗病毒作用之外，NK还参与适当下游T细胞应答的诱导和引发。在慢性HCV的背景下，总体NK细胞水平降低，改变了亚群分布，NK受体（NKR）表达的变化已被证明，尽管单个NKR对病毒清除或持续存在的贡献仍有待澄清。在慢性感染的情况下，NK细胞的细胞毒性增强伴随干扰素-γ产生不足可能会促进肝损伤。治疗诱导的清除与NK细胞的活化相关，监测NK细胞对三联疗法的反应将是有意义的。活化的NK细胞也具有抗纤维化特性，并且积极参与控制HCV的相同肝NK细胞群体也可能参与控制HCV相关的肝损伤。我们仍然有很多东西需要学习，特别是：肝源性NK如何影响HCV感染的结果？NK受体识别HCV特异性成分吗？HCV特异性记忆NK细胞群是否产生？
Natural killer cells (NKs) are involved in every stage of hepatitis C viral (HCV) infection, from protection against HCV acquisition and resolution in the acute phase to treatment-induced clearance. In addition to their direct antiviral actions, NKs are involved in the induction and priming of appropriate downstream T-cell responses. In the setting of chronic HCV, overall NK cell levels are decreased, altered subset distribution is altered, and changes in NK receptor (NKR) expression have been demonstrated, although the contribution of individual NKRs to viral clearance or persistence remains to be clarified. Enhanced NK cell cytotoxicity accompanied by insufficient interferon-γ production may promote liver damage in the setting of chronic infection. Treatment-induced clearance is associated with activation of NK cells, and it will be of interest to monitor NK cell responses to triple therapy. Activated NK cells also have antifibrotic properties, and the same hepatic NK cell populations that are actively involved in control of HCV may also be involved in control of HCV-associated liver damage. We still have much to learn, in particular: how do liver-derived NKs influence the outcome of HCV infection? Do NK receptors recognize HCV-specific components? And, are HCV-specific memory NK populations generated?
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影响因子：
3.7
作者：
Abdul-Careem MF;Lee AJ;Pek EA;Gill N;Gillgrass AE;Chew MV;Reid S;Ashkar AA
通讯作者：
Ashkar AA
DOI：
10.1038/nri2935
发表时间：
2011-03
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
56.9
作者：
Brown, MG;Dokun, AO;Yokoyama, WM
通讯作者：
Yokoyama, WM
影响因子：
56.9
作者：
Bauer, S;Groh, V;Spies, T
通讯作者：
Spies, T
影响因子：
25.7
作者：
Alter G;Jost S;Rihn S;Reyor LL;Nolan BE;Ghebremichael M;Bosch R;Altfeld M;Lauer GM
通讯作者：
Lauer GM