Leucine-rich repeat receptor kinases are sporadically distributed in eukaryotic genomes.
Leucine-rich repeat receptor kinases are sporadically distributed in eukaryotic genomes.
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DOI：
10.1186/1471-2148-11-367
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发表时间：
2011-12-20
影响因子：
3.4
通讯作者：
Périn C
中科院分区：
文献类型：
--
作者：
Diévart A;Gilbert N;Droc G;Attard A;Gourgues M;Guiderdoni E;Périn C
植物富含亮氨酸的重复受体样激酶（LRR-RLKs）是在细胞外区域含有lrr的受体激酶。在过去的15年里，许多研究小组已经证明了LRR-RLKs在植物整个生命周期的几乎所有发育过程中都发挥着重要作用，并在防御/抵抗多种病原体方面发挥着重要作用。最近，这一领域取得了突破性进展，挑战了植物LRR-RLKs特异性的教条。我们分析了大约1000个完整的基因组，发现LRR-RK基因目前已经在8个非植物基因组中被鉴定出来。我们对所有这些受体进行了详尽的系统发育分析，揭示了所有含有lrr的受体亚家族形成了谱系特异性分支。我们的研究结果表明，lrr与RKs的关联在真核生物进化史上至少独立出现了四次。此外，卵菌中发现的LRR-RKs的分子进化史与植物中观察到的模式相似：扩增/缺失和结构域组织的进化导致基因家族成员的功能多样化。最后，这些表达数据表明卵菌LRR-RKs可能在卵菌生命周期的几个阶段发挥作用。鉴于LRR-RLKs在植物的整个生命周期和植物与环境的相互作用中发挥的关键作用，这类受体在真核生物进化过程中在几个门中的出现和扩展，特别是在卵菌基因组中的出现和扩展，质疑它们在宿主和病原体之间受体的模仿和/或共同进化中的内在功能。
Plant leucine-rich repeat receptor-like kinases (LRR-RLKs) are receptor kinases that contain LRRs in their extracellular domain. In the last 15 years, many research groups have demonstrated major roles played by LRR-RLKs in plants during almost all developmental processes throughout the life of the plant and in defense/resistance against a large range of pathogens. Recently, a breakthrough has been made in this field that challenges the dogma of the specificity of plant LRR-RLKs. We analyzed ~1000 complete genomes and show that LRR-RK genes have now been identified in 8 non-plant genomes. We performed an exhaustive phylogenetic analysis of all of these receptors, revealing that all of the LRR-containing receptor subfamilies form lineage-specific clades. Our results suggest that the association of LRRs with RKs appeared independently at least four times in eukaryotic evolutionary history. Moreover, the molecular evolutionary history of the LRR-RKs found in oomycetes is reminiscent of the pattern observed in plants: expansion with amplification/deletion and evolution of the domain organization leading to the functional diversification of members of the gene family. Finally, the expression data suggest that oomycete LRR-RKs may play a role in several stages of the oomycete life cycle. In view of the key roles that LRR-RLKs play throughout the entire lifetime of plants and plant-environment interactions, the emergence and expansion of this type of receptor in several phyla along the evolution of eukaryotes, and particularly in oomycete genomes, questions their intrinsic functions in mimicry and/or in the coevolution of receptors between hosts and pathogens.
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影响因子：
7.4
作者：
Shiu, SH;Bleecker, AB
通讯作者：
Bleecker, AB
影响因子：
14.9
作者：
Letunic I;Doerks T;Bork P
通讯作者：
Bork P
影响因子：
3.7
作者：
Soanes DM;Talbot NJ
通讯作者：
Talbot NJ
DOI：
10.1111/j.1365-313x.2011.04518.x
发表时间：
2011-04
期刊：
The Plant journal : for cell and molecular biology
影响因子：
--
作者：
Gish LA;Clark SE
通讯作者：
Clark SE
影响因子：
20.5
作者：
Chinchilla, Delphine;Shan, Libo;He, Ping;de Vries, Sacco;Kemmerling, Birgit
通讯作者：
Kemmerling, Birgit