Monitoring peripheral hemodynamic response to changes in blood pressure via photoacoustic imaging.
Monitoring peripheral hemodynamic response to changes in blood pressure via photoacoustic imaging.
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DOI：
10.1016/j.pacs.2022.100345
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发表时间：
2022-06
期刊：
影响因子：
7.9
通讯作者：
Jokerst JV
中科院分区：
文献类型：
--
作者：
Mantri Y;Dorobek TR;Tsujimoto J;Penny WF;Garimella PS;Jokerst JV
慢性伤口和截肢在需要血液透析（HD）的慢性肾病患者中很常见。HD通常并发血压（BP）下降，称为透析中低血压。透析中低血压是否与足部灌注的可检测变化相关，这是伤口形成和愈合受损的风险因素，目前尚不清楚。光声（PA）成像非常适合研究灌注变化。我们扫描了20名HD和11名健康受试者的足部。HD患者在透析前后进行扫描，而健康受试者在休息时扫描两次，在BP升高的10分钟运动期后扫描一次。健康人（r = 0.70，p < 0.0001）和HD受试者（r = 0.43，p < 0.01）显示PA强度与收缩压之间存在显著相关性。此外，与健康对照组相比，HD组显示PA对BP变化的反应显著降低（p < 0.0001），表明PA可以监测由于BP变化引起的血流动力学变化。
Chronic wounds and amputations are common in chronic kidney disease patients needing hemodialysis (HD). HD is often complicated by drops in blood pressure (BP) called intra-dialytic hypotension. Whether intra-dialytic hypotension is associated with detectable changes in foot perfusion, a risk factor for wound formation and impaired healing remains unknown. Photoacoustic (PA) imaging is ideally suited to study perfusion changes. We scanned the feet of 20 HD and 11 healthy subjects. HD patients were scanned before and after a dialysis session whereas healthy subjects were scanned twice at rest and once after a 10 min exercise period while BP was elevated. Healthy (r = 0.70, p < 0.0001) and HD subjects (r = 0.43, p < 0.01) showed a significant correlation between PA intensity and systolic BP. Furthermore, HD cohort showed a significantly reduced PA response to changes in BP compared to the healthy controls (p < 0.0001), showing that PA can monitor hemodynamic changes due to changes in BP.
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影响因子：
7.9
作者：
Hariri A;Lemaster J;Wang J;Jeevarathinam AS;Chao DL;Jokerst JV
通讯作者：
Jokerst JV
影响因子：
3.1
作者：
Lavery, Lawrence A.;Lavery, David C.;Boulton, Andrew J.
通讯作者：
Boulton, Andrew J.
影响因子：
3.5
作者：
Hariri, Ali;Wang, Junxin;Jokerst, Jesse V.
通讯作者：
Jokerst, Jesse V.
影响因子：
3.5
作者：
Choi, Min;Shapiro, A. M. James;Zemp, Roger
通讯作者：
Zemp, Roger
影响因子：
3.3
作者：
Kmiec, Maciej M.;Hou, Huagang;Kuppusamy, Periannan
通讯作者：
Kuppusamy, Periannan