Prognostic values of red blood cell distribution width, platelet count, and red cell distribution width-to-platelet ratio for severe burn injury.
Prognostic values of red blood cell distribution width, platelet count, and red cell distribution width-to-platelet ratio for severe burn injury.
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红细胞分布宽度、血小板计数及红细胞分布宽度与血小板比对严重烧伤的预后价值
DOI：
10.1038/s41598-017-13151-3
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发表时间：
2017-10-20
影响因子：
4.6
通讯作者：
Chen XL
中科院分区：
文献类型：
--
作者：
Qiu L;Chen C;Li SJ;Wang C;Guo F;Peszel A;Liu S;Wang F;Sun YX;Wang YJ;Chen XL
红细胞分布宽度（RDW）、血小板计数（PLT）和RDW/PLT比值（RPR）与许多疾病的炎症活动和不良结局相关。本研究旨在探讨这些指标与严重烧伤患者死亡率之间的关系。2008年至2014年，来自中国东部两个烧伤中心的610例重度烧伤患者入选本研究。88例患者在入院后90天内死亡。采用考克斯回归分析方法对第3、7天的RDW、PLT、RPR进行分析。第3、7天的RDW、PLT、RPR值与严重烧伤患者的预后显著相关（P < 0.01）。高RPR与两个时间点的90天死亡率显著相关。然而，RDW和PLT没有提供独立的预测值。结果表明，第3、7天RPR值与严重烧伤病人死亡率有关（P < 0.01）。同时，这些时间点的RDW和PLT值未能提供烧伤死亡率预测的独立值。因此，RPR可以作为一个独立的和新的指标预测严重烧伤患者的死亡率。
Red blood cell distribution width (RDW), platelet count (PLT), and a RDW-to-PLT ratio (RPR) have been associated with inflammatory activity and adverse outcomes in many diseases. This study has aimed to investigate the association between these indicators and the mortality rate of severe burn patients. From 2008 to 2014, 610 cases of severe burn patients from two burn centers in eastern China were enrolled in this study. Eighty-eight patients died within 90 days after admission. The RDW, PLT, and RPR were studied through Cox regression analysis on the 3rd and 7th day. The RDW, PLT, and RPR values on the 3rd and 7th day were significantly associated with the outcomes of severe burn patients (P < 0.01). High RPR was significantly associated with a 90-day mortality rate at the two time points. However, the RDW and PLT did not provide independent predictive values. Our results indicated that the RPR values on the 3rd and 7th day were associated with the mortality rates of severe burn patients (P < 0.01). Meanwhile, the RDW and PLT values at these time points failed to provide independent values for burn mortality prediction. Thus, the RPR can serve as an independent and novel marker for mortality rates prediction in severe burn patients.
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影响因子：
--
作者：
Sun P;Zhang F;Chen C;Bi X;Yang H;An X;Wang F;Jiang W
通讯作者：
Jiang W
影响因子：
--
作者：
Patel, Kushang V.;Ferrucci, Luigi;Ershler, William B.;Longo, Dan L.;Guralnik, Jack M.
通讯作者：
Guralnik, Jack M.
DOI：
10.1186/cc9300
发表时间：
2010
期刊：
Critical care (London, England)
影响因子：
--
作者：
Brusselaers N;Monstrey S;Vogelaers D;Hoste E;Blot S
通讯作者：
Blot S
影响因子：
1.9
作者：
Oryan, A.;Alemzadeh, E.;Moshiri, A.
通讯作者：
Moshiri, A.
影响因子：
2.9
作者：
Marck, Roos E.;Gardien, Kim L. M.;Middelkoop, Esther
通讯作者：
Middelkoop, Esther