The ratio of hemoglobin to red cell distribution width as a novel prognostic parameter in esophageal squamous cell carcinoma: a retrospective study from southern China.
The ratio of hemoglobin to red cell distribution width as a novel prognostic parameter in esophageal squamous cell carcinoma: a retrospective study from southern China.
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DOI：
10.18632/oncotarget.9516
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发表时间：
2016-07-05
期刊：
影响因子：
--
通讯作者：
Jiang W
中科院分区：
文献类型：
--
作者：
Sun P;Zhang F;Chen C;Bi X;Yang H;An X;Wang F;Jiang W
我们提出了一个新的食管鳞状细胞癌（ESCC）的预后参数-血红蛋白/红细胞分布宽度（HB/RDW）比值。探讨其临床预后价值及其与其他临床病理特征的关系。HB/RDW比值的最佳临界值为0.989。多因素分析显示HB/RDW比值（P= 0.035）、肿瘤深度（P = 0.020）和淋巴结状况（P<0.001）是影响OS的独立预后因素，Bootstrap检验证实了这一点。HB/RDW比值低的患者在随访期间的死亡风险是HB/RDW比值高的患者的1.416倍（95%CI = 1.024-1.958，P = 0.035）。我们回顾性分析了2007年1月至2008年12月期间在单一机构接受根治性治疗的362例患者。采用卡方检验评估HB/RDW比值与其他临床病理变量之间的关系; Kaplan-Meier法分析5年总生存率（OS）;考克斯比例风险模型用于OS相关变量的单变量和多变量分析。基于这些发现，我们认为HB/RDW比值是ESCC患者一个新的和有前途的预后参数。
We propose a novel prognostic parameter for esophageal squamous cell carcinoma (ESCC)—hemoglobin/red cell distribution width (HB/RDW) ratio. Its clinical prognostic value and relationship with other clinicopathological characteristics were investigated in ESCC patients. The optimal cut-off value was 0.989 for the HB/RDW ratio. The HB/RDW ratio (P= 0.035), tumor depth (P = 0.020) and lymph node status (P<0.001) were identified to be an independent prognostic factors of OS by multivariate analysis, which was validated by bootstrap resampling. Patients with a low HB/RDW ratio had a 1.416 times greater risk of dying during follow-up compared with those with a high HB/RDW (95% CI = 1.024–1.958, P = 0.035). We retrospectively analyzed 362 patients who underwent curative treatment at a single institution between January 2007 and December 2008. The chi-square test was used to evaluate relationships between the HB/RDW ratio and other clinicopathological variables; the Kaplan–Meier method was used to analyze the 5-year overall survival (OS); and the Cox proportional hazards models were used for univariate and multivariate analyses of variables related to OS. A significant association was found between the HB/RDW ratio and clinical characteristics and survival outcomes in ESCC patients. Based on these findings, we believe that the HB/RDW ratio is a novel and promising prognostic parameter for ESCC patients.
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影响因子：
1.5
作者：
Agarwal, Shikhar
通讯作者：
Agarwal, Shikhar
DOI：
10.1186/1758-3284-3-35
发表时间：
2011-08-15
期刊：
Head & neck oncology
影响因子：
--
作者：
Cordella C;Luebbers HT;Rivelli V;Grätz KW;Kruse AL
通讯作者：
Kruse AL
影响因子：
--
作者：
Albayrak, Sebahattin;Zengin, Kursad;Gurdal, Mesut
通讯作者：
Gurdal, Mesut
影响因子：
3.8
作者：
Jiang D;Li X;Wang H;Shi Y;Xu C;Lu S;Huang J;Xu Y;Zeng H;Su J;Hou Y;Tan L
通讯作者：
Tan L
DOI：
10.1093/jnci/djn211
发表时间：
2008-08-20
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Brown LM;Devesa SS;Chow WH
通讯作者：
Chow WH