The relationship between levels of PCBs and pesticides in human hair and blood: preliminary result.
The relationship between levels of PCBs and pesticides in human hair and blood: preliminary result.
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PCBS水平与人毛中的农药之间的关系：初步结果。
DOI：
10.1289/ehp.6916
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发表时间：
2004-08
影响因子：
10.4
通讯作者：
Hauser R
中科院分区：
文献类型：
--
作者：
Altshul L;Covaci A;Hauser R
人类毛发作为持久性有机污染物暴露的生物测量方法比更常用的血液和脂肪组织样本具有一些优势。然而，主要的限制之一是难以区分外源性和内源性污染。此外，目前还没有标准化的方法来收集头发样本，清洗和化学分析。关于头发中有机污染物水平与身体其他部位之间的相关性的信息也非常有限。为了探索血液和头发中的持久性有机污染物水平，从10名志愿者那里收集了样本，并分析了选定的有机氯农药和57种多氯联苯（PCB）同系物。我们证明，用于分析人发中的有机污染物的方法是可靠的和可重复的。用洗发水洗头可使多氯联苯、杀虫剂和脂质的含量平均降低25-33%，而低氯化同系物的含量可高达62%。头发中的脂类含量和有机氯含量均高于血清。我们发现头发和血液中p，p′-DDE（二氯二苯基二氯乙烯）水平之间存在很强的相关性（r = 0.8），而持久性更强的PCB同系物之间存在中等程度的相关性，但其他有机氯没有相关性或相关性较弱。本研究提供了关于毛发分析对持久性有机污染物的效用的初步证据;然而，在毛发分析成功地应用于持久性有机污染物的流行病学研究之前，建议进行更大规模的研究。
Human hair as a biologic measure of exposure to persistent organic pollutants (POPs) has some advantages over the more commonly used blood and adipose tissue samples. However, one of the primary limitations is the difficulty in distinguishing between exogenous and endogenous contamination. In addition, there are currently no standardized methods for hair sample collection, washing, and chemical analysis. There is also very limited information describing the correlation between levels of organic contaminants in hair and other body compartments. To explore levels of POPs in blood and hair, samples from 10 volunteers were collected and analyzed for select organochlorine pesticides and 57 individual polychlorinated biphenyl (PCB) congeners. We demonstrated that the method for analyzing organic contaminants in human hair was reliable and reproducible. Washing hair with shampoo decreased levels of PCBs, pesticides, and lipids by 25–33% on average and up to 62% for low-chlorinated congeners. The percentage of lipids and the levels of organochlorines in hair were higher than in serum. We found strong correlation (r = 0.8) between p,p′-DDE (dichlorodiphenyldichloroethylene) levels in hair and blood and moderate correlations for the more persistent PCB congeners, but no correlations or weak correlations for other organochlorines. The present study provides preliminary evidence on the utility of hair analysis for POPs; however, further larger studies are recommended before hair analysis can be successfully applied in epidemiologic studies on POPs.
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影响因子：
8.3
作者：
Covaci, A;de Boer, J;Schepens, P
通讯作者：
Schepens, P
DOI：
10.1080/15287399409531870
发表时间：
1994-06-01
期刊：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH
影响因子：
--
作者：
JOHANSEN, HR;BECHER, G;SKAARE, JU
通讯作者：
SKAARE, JU
DOI：
10.1007/bf00322786
发表时间：
1990-01-01
期刊：
FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY
影响因子：
--
作者：
BENCZE, K
通讯作者：
BENCZE, K
影响因子：
9.8
作者：
Covaci, A;Jorens, P;Schepens, R
通讯作者：
Schepens, R
DOI：
10.1038/sj.jea.7500111
发表时间：
2000-11-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Seifert, B;Becker, K;Seiwert, M
通讯作者：
Seiwert, M