Engineering defected 2D Pd/H-TiO(2) nanosonosensitizers for hypoxia alleviation and enhanced sono-chemodynamic cancer nanotherapy.
Engineering defected 2D Pd/H-TiO(2) nanosonosensitizers for hypoxia alleviation and enhanced sono-chemodynamic cancer nanotherapy.
复制标题
用于缓解缺氧和增强声化学动力学癌症纳米治疗的工程缺陷二维 Pd/H-TiO2 纳米声敏剂
DOI：
10.1186/s12951-022-01398-6
复制
发表时间：
2022-04-12
影响因子：
10.2
通讯作者：
Ding, Hong
中科院分区：
文献类型：
--
作者：
Qiao, Xiaohui;Xue, Liyun;Huang, Hui;Dai, Xinyue;Chen, Yu;Ding, Hong
背景
声动力疗法（SDT）因其高组织穿透能力、可控性和安全性而成为一种新兴的癌症治疗方式。然而，声敏剂产生的不良活性氧（ROS）和肿瘤缺氧是 SDT 的两个薄弱环节。因此，提高ROS水平并同时缓解缺氧是SDT充分发挥癌症治疗潜力的明智策略。
结果
在这项工作中，具有三重抗肿瘤特性的有缺陷的二维（2D）Pd/H-TiO2纳米片（NSs）被巧妙地精心设计和设计，使用一种简单的一锅式Pd催化氢化策略，通过负载少量的Pd，然后在大气压和温度下引入氢气流。具有氧缺陷的二维黑色 Pd/H-TiO2 NSs 由于带隙减小而发挥了出色的 SDT 效应，在密度泛函理论计算的理论指导下，当超声波触发时，电子和空穴更容易分离。此外，由于氧缺陷的存在，Pd/H-TiO2 NSs可以作为类芬顿剂，促进过氧化氢转化为羟基自由基，从而发挥化学动力学疗法（CDT）。同时，引入的微小Pd成分具有类似过氧化氢酶的活性，负责产生氧气以改善缺氧状况，从而有助于提高SDT和CDT的功效。体外和体内结果都提供了令人信服的证据，证明 Pd/H-TiO2 纳米声敏剂的高 ROS 产量和增强的声化学动力学效应，并通过 RNA 测序进行了详细的潜在机制研究。
结论
这项工作深入研究了钯催化氢化二氧化钛在肿瘤治疗方面的巨大潜力，有效的抗肿瘤性能和可忽略的治疗毒性使其成为众多纳米声敏剂中的有力竞争者。
图解摘要
Background
Sonodynamic therapy (SDT) is a burgeoning modality for cancer therapy owing to its high tissue-penetrating capability, controllability and safety. Whereas, the undesirable reactive oxygen species (ROS) yield of sonosensitizers and tumor hypoxia are two vulnerable spots of SDT. Therefore, it is an advisable strategy to augment ROS level and simultaneously relieve hypoxia for SDT to arrive its full potential in cancer treatment.
Results
In this work, the defected two-dimensional (2D) Pd/H-TiO2 nanosheets (NSs) with triple antineoplastic properties were dexterously elaborated and engineered using a facile one-pot Pd-catalyzed hydrogenation tactic by loading a tiny amount of Pd and then inletting hydrogen flow at atmospheric pressure and temperature. The 2D black Pd/H-TiO2 NSs with oxygen defects exerted eximious SDT effect based on the decreased bandgap that made it easier for the separation of electrons and holes when triggered by ultrasound as theoretically guided by density functional theory calculations. Additionally, Pd/H-TiO2 NSs could serve as Fenton-like agents because of the presence of oxygen defects, facilitating the conversion of hydrogen peroxide into hydroxyl radicals for exerting the chemodynamic therapy (CDT). Simultaneously, the introduced tiny Pd component possessed catalase-like activity responsible for oxygen production to ameliorate hypoxic condition and thus contributed to improving SDT and CDT efficacies. Both in vitro and in vivo results provided compelling evidences of high ROS yield and aggrandized sono-chemodynamic effect of Pd/H-TiO2 nanosonosensitizers with the detailed underlying mechanism investigation by RNA sequencing.
Conclusion
This work delves the profound potential of Pd-catalyzed hydrogenated TiO2 on oncotherapy, and the effective antineoplastic performance and ignorable therapeutic toxicity make it a powerful competitor among a cornucopia of nanosonosensitizers.
Graphical Abstract
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DOI：
10.1016/j.mric.2017.06.004
发表时间：
2017-11-01
影响因子：
1.6
作者：
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通讯作者：
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影响因子：
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影响因子：
29.4
作者：
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DOI：
10.1002/advs.202002178
发表时间：
2021-05
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
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作者：
Gong Z;Dai Z
通讯作者：
Dai Z