Effect of animal and industrial trans fatty acids on HDL and LDL cholesterol levels in humans--a quantitative review.
Effect of animal and industrial trans fatty acids on HDL and LDL cholesterol levels in humans--a quantitative review.
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DOI：
10.1371/journal.pone.0009434
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发表时间：
2010-03-02
期刊：
影响因子：
3.7
通讯作者：
Katan MB
中科院分区：
文献类型：
--
作者：
Brouwer IA;Wanders AJ;Katan MB
反式脂肪酸可以通过工业氢化或生物氢化在牛和羊的瘤胃中生产。工业反式脂肪酸降低高密度脂蛋白胆固醇，提高低密度脂蛋白胆固醇，并增加冠心病的风险。反刍动物共轭亚油酸和反式脂肪酸的作用尚不清楚。我们回顾了文献，估计了反刍动物来源的反式脂肪酸和共轭反式亚油酸（CLA）对血脂的影响，并将其与工业反式脂肪酸进行了比较。我们检索了Medline，并扫描了有关工业反式脂肪酸、反刍动物反式脂肪酸或共轭亚油酸对人类低密度脂蛋白和高密度脂蛋白胆固醇影响的干预试验的参考文献。符合我们标准的39项研究提供了29项工业反式脂肪酸处理的结果，6项反刍动物反式脂肪酸处理的结果，17项CLA处理的结果。研究之间的对照治疗存在差异；为了进行研究间的比较，我们重新计算了如果反式脂肪酸以等热量取代顺式单不饱和脂肪酸，反式脂肪酸对脂蛋白的影响。线性回归分析表明，工业反式脂肪酸替代顺式单不饱和脂肪酸每增加饲粮能量%，血浆LDL / HDL比值提高0.055 (95%CI 0.044 ~ 0.066)，反刍动物反式脂肪酸每增加饲粮能量%，LDL / HDL比值提高0.038 (95%CI 0.012 ~ 0.065)，共轭亚油酸每增加饲粮能量%，LDL / HDL比值提高0.043 (95%CI 0.012 ~ 0.074) (CLA与工业反式脂肪酸差异p = 0.99)；反刍动物与工业反式脂肪酸的对比P = 0.37)。已发表的数据表明，所有在反式结构中带有双键的脂肪酸都能提高血浆中低密度脂蛋白与高密度脂蛋白的比值。
Trans fatty acids are produced either by industrial hydrogenation or by biohydrogenation in the rumens of cows and sheep. Industrial trans fatty acids lower HDL cholesterol, raise LDL cholesterol, and increase the risk of coronary heart disease. The effects of conjugated linoleic acid and trans fatty acids from ruminant animals are less clear. We reviewed the literature, estimated the effects trans fatty acids from ruminant sources and of conjugated trans linoleic acid (CLA) on blood lipoproteins, and compared these with industrial trans fatty acids. We searched Medline and scanned reference lists for intervention trials that reported effects of industrial trans fatty acids, ruminant trans fatty acids or conjugated linoleic acid on LDL and HDL cholesterol in humans. The 39 studies that met our criteria provided results of 29 treatments with industrial trans fatty acids, 6 with ruminant trans fatty acids and 17 with CLA. Control treatments differed between studies; to enable comparison between studies we recalculated for each study what the effect of trans fatty acids on lipoprotein would be if they isocalorically replaced cis mono unsaturated fatty acids. In linear regression analysis the plasma LDL to HDL cholesterol ratio increased by 0.055 (95%CI 0.044–0.066) for each % of dietary energy from industrial trans fatty acids replacing cis monounsaturated fatty acids The increase in the LDL to HDL ratio for each % of energy was 0.038 (95%CI 0.012–0.065) for ruminant trans fatty acids, and 0.043 (95% CI 0.012–0.074) for conjugated linoleic acid (p = 0.99 for difference between CLA and industrial trans fatty acids; p = 0.37 for ruminant versus industrial trans fatty acids). Published data suggest that all fatty acids with a double bond in the trans configuration raise the ratio of plasma LDL to HDL cholesterol.
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影响因子：
7.1
作者：
Chardigny, Jean-Michel;Destaillats, Frederic;Sebedio, Jean-Louis
通讯作者：
Sebedio, Jean-Louis
影响因子：
1.9
作者：
Judd, JT;Baer, DJ;Iwane, M
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影响因子：
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作者：
ANDERSON, JT;LAWLER, A;KEYS, A
通讯作者：
KEYS, A
影响因子：
4.2
作者：
de Roos, NM;Schouten, EG;Katan, MB
通讯作者：
Katan, MB
影响因子：
7.1
作者：
Desroches, S;Chouinard, PY;Bergeron, N
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