Sleep promotes consolidation of emotional memory in healthy children but not in children with attention-deficit hyperactivity disorder.
Sleep promotes consolidation of emotional memory in healthy children but not in children with attention-deficit hyperactivity disorder.
复制标题
DOI：
10.1371/journal.pone.0065098
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Baving L
中科院分区：
文献类型：
--
作者：
Prehn-Kristensen A;Munz M;Molzow I;Wilhelm I;Wiesner CD;Baving L
睡眠时大脑额边缘的活动被认为支持健康成年人情绪记忆的巩固。注意缺陷多动障碍（ADHD）是由额边缘神经回路功能失调引起的情绪缺陷。本研究旨在探讨在健康发展的背景下，睡眠在ADHD患者情绪记忆巩固中的作用。16名ADHD儿童，16名健康儿童和20名健康成人参与了这项研究。参与者在睡眠和清醒控制条件下完成了情绪图片识别范式。每个条件都有一个即时（基线）和延迟（目标）检索会话。对情绪记忆偏差进行了基线校正，并对各组进行了睡眠依赖性记忆巩固（睡眠与清醒）的比较。我们观察到，与患有ADHD的儿童和健康成人相比，健康儿童的睡眠依赖性情绪记忆偏差增加。睡眠期间额叶振荡脑电图活动（慢振荡，θ）与多动症儿童的情绪记忆表现呈负相关。当结合健康儿童和成人的数据时，相关系数为正，与ADHD儿童的相关系数不同。由于儿童表现出比成人更高的额叶脑电图活动，这些数据表明，在健康发育过程中，与睡眠相关的情绪记忆巩固有所下降。此外，研究表明，ADHD患者在情绪和非情绪记忆之间的睡眠相关选择缺陷加剧了白天的情绪问题，正如ADHD患者经常报道的那样。
Fronto-limbic brain activity during sleep is believed to support the consolidation of emotional memories in healthy adults. Attention deficit-hyperactivity disorder (ADHD) is accompanied by emotional deficits coincidently caused by dysfunctional interplay of fronto-limbic circuits. This study aimed to examine the role of sleep in the consolidation of emotional memory in ADHD in the context of healthy development. 16 children with ADHD, 16 healthy children, and 20 healthy adults participated in this study. Participants completed an emotional picture recognition paradigm in sleep and wake control conditions. Each condition had an immediate (baseline) and delayed (target) retrieval session. The emotional memory bias was baseline–corrected, and groups were compared in terms of sleep-dependent memory consolidation (sleep vs. wake). We observed an increased sleep-dependent emotional memory bias in healthy children compared to children with ADHD and healthy adults. Frontal oscillatory EEG activity (slow oscillations, theta) during sleep correlated negatively with emotional memory performance in children with ADHD. When combining data of healthy children and adults, correlation coefficients were positive and differed from those in children with ADHD. Since children displayed a higher frontal EEG activity than adults these data indicate a decline in sleep-related consolidation of emotional memory in healthy development. In addition, it is suggested that deficits in sleep-related selection between emotional and non-emotional memories in ADHD exacerbate emotional problems during daytime as they are often reported in ADHD.
登录
查看更多内容
影响因子：
2.7
作者：
GIUDITTA, A;AMBROSINI, MV;VESCIA, S
通讯作者：
VESCIA, S
影响因子：
5.3
作者：
Connor, Daniel F.;Ford, Julian D.
通讯作者：
Ford, Julian D.
DOI：
10.1073/pnas.1120860109
发表时间：
2012-04-10
影响因子：
11.1
作者：
Campbell, Ian G.;Grimm, Kevin J.;Feinberg, Irwin
通讯作者：
Feinberg, Irwin
DOI：
10.1176/appi.ajp.2009.09010043
发表时间：
2010-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Brotman MA;Rich BA;Guyer AE;Lunsford JR;Horsey SE;Reising MM;Thomas LA;Fromm SJ;Towbin K;Pine DS;Leibenluft E
通讯作者：
Leibenluft E
DOI：
10.1055/s-2003-814786
发表时间：
2004-05-01
影响因子：
0.9
作者：
Hardt, J;Egle, UT;Brähler, E
通讯作者：
Brähler, E