Temporal exposure and consistency of endocrine disrupting chemicals in a longitudinal study of individuals with impaired fasting glucose.
Temporal exposure and consistency of endocrine disrupting chemicals in a longitudinal study of individuals with impaired fasting glucose.
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空腹血糖受损个体纵向研究中内分泌干扰物的时间暴露和一致性。
DOI：
10.1016/j.envres.2021.110901
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发表时间：
2021-06
影响因子：
8.3
通讯作者：
Patel, Chirag J.
中科院分区：
文献类型：
--
作者：
van der Meer, Thomas P.;Chung, Ming K.;van Faassen, Martijn;Makris, Konstantinos C.;van Beek, Andre P.;Kema, Ido P.;Wolffenbuttel, Bruce H. R.;Van Vliet-Ostaptchouk, Jana V.;Patel, Chirag J.
内分泌干扰物（EDCs）包括非持久性外源性物质，如对羟基苯甲酸酯，双酚和邻苯二甲酸酯，它们与一系列代谢紊乱和疾病有关。目前尚不清楚暴露是否随时间保持一致。我们调查了2009年至2016年期间EDC暴露指标的变化，并在荷兰个体样本中评估了个体之间和个体内的一致性，中位随访时间为47个月。在500名荷兰人中，分析了两份24小时尿样中的5种对羟基苯甲酸酯、3种双酚和13种代谢物，共8种不同的邻苯二甲酸酯。我们使用荟萃分析计算每年的差异，并使用斯皮尔曼相关系数、类内相关系数（ICC）和卡帕统计评估个体之间和个体内的时间相关性。我们发现，2009年至2016年期间，对羟基苯甲酸甲酯、对羟基苯甲酸乙酯、对羟基苯甲酸丙酯和对羟基苯甲酸正丁酯、双酚A以及邻苯二甲酸二乙酯（DEP）、邻苯二甲酸二丁酯（DBP）、邻苯二甲酸二（2-乙基己基）酯（DEHP）和邻苯二甲酸丁基苄酯（DBzP）的代谢物浓度长期下降，范围为8%至96%（对羟基苯甲酸乙酯、对羟基苯甲酸丙酯）。对羟基苯甲酸酯（ICC：0.34至0.40）和双酚（ICC：0.15至0.23）最差的人内时间相关性最高。对于邻苯二甲酸酯代谢物，时间段之间的相关性下降最多（ICC < 48个月：0.22至0.39; ≥ 48个月：-0.05至0.32）。当对EDC浓度进行分类时，33%至54%的个体仍处于最低或最高类别，时间相关性与连续测量相似。在2009年至2016年期间，来自荷兰人群的空腹血糖受损个体样本中，大多数内分泌干扰物的暴露量都有所下降。时间一致性普遍较差。疾病关联的不一致性可能受到EDCs表现出的个体水平或时间变化的影响。我们的研究结果要求在观察性研究中，在疾病的风险时间窗之前和期间，需要重复测量EDCs。
Endocrine disrupting chemicals (EDCs) include non-persistent exogenous substances such as parabens, bisphenols and phthalates which have been associated with a range of metabolic disorders and disease. It is unclear if exposure remains consistent over time. We investigated change in indicators of EDC exposure between 2009 and 2016 and assessed its consistency between and within individuals over a median follow-up time of 47 months in a sample of Dutch individuals. Of 500 Dutch individuals, two 24 hour urine samples were analysed for 5 parabens, 3 bisphenols and 13 metabolites of in total 8 different phthalates. We calculated per-year differences using meta-analysis and assessed temporal correlations between and within individuals using Spearman correlation coefficients, intra-class correlation coefficients (ICC) and kappa-statistics. We found a secular decrease in concentrations of methyl, ethyl, propyl and n-butyl paraben, bisphenol A, and metabolites of di-ethyl phthalate (DEP), di-butyl phthalate (DBP), di-(2-ethyl-hexyl) phthalate (DEHP), and butylbenzyl phthalate (DBzP) which varied from 8 to 96% (ethyl paraben, propyl paraben) between 2009 and 2016. Within-person temporal correlations were highest for parabens (ICC: 0.34 to 0.40) and poorest for bisphenols (ICC: 0.15 to 0.23). For phthalate metabolites, correlations decreased most between time periods (ICC < 48 months: 0.22 to 0.39; ≥ 48 months: −0.05 to 0.32). When categorizing EDC concentrations, 33 to 54% of individuals remained in the lowest or highest category and temporal correlations were similar to continuous measurements. Exposure to most EDCs decreased between 2009 and 2016 in a sample of individuals with impaired fasting glucose from the Dutch population. Temporal consistency was generally poor. The inconsistency in disease associations may be influenced by individual-level or temporal variation exhibited by EDCs. Our findings call for the need for repeated measurements of EDCs in observational studies before and during at-risk temporal windows for the disease.
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DOI：
10.1016/j.ijheh.2015.07.005
发表时间：
2015-10-01
影响因子：
6
作者：
Moos, Rebecca K.;Koch, Holger M.;Kolossa-Gehring, Marike
通讯作者：
Kolossa-Gehring, Marike
影响因子：
7.1
作者：
Sun, Qi;Bertrand, Kimberly A.;Willett, Walter C.
通讯作者：
Willett, Walter C.
影响因子：
4.6
作者：
van der Meer, Thomas P.;van Faassen, Martijn;van Vliet-Ostaptchouk, Jana V.
通讯作者：
van Vliet-Ostaptchouk, Jana V.
影响因子：
10.4
作者：
Rudel RA;Gray JM;Engel CL;Rawsthorne TW;Dodson RE;Ackerman JM;Rizzo J;Nudelman JL;Brody JG
通讯作者：
Brody JG
影响因子：
--
作者：
Janjua, Nadeem Rezaq;Frederiksen, Hanne;Andersson, Anna-Maria
通讯作者：
Andersson, Anna-Maria