Different effects of running wheel exercise and skilled reaching training on corticofugal tract plasticity in hypertensive rats with cortical infarctions
Different effects of running wheel exercise and skilled reaching training on corticofugal tract plasticity in hypertensive rats with cortical infarctions
复制标题
跑轮运动和熟练伸手训练对高血压皮质梗死大鼠皮质束可塑性的不同影响
DOI：
10.1016/j.bbr.2017.09.002
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发表时间：
2018-01
影响因子：
2.7
通讯作者：
HongMei Wen
中科院分区：
文献类型：
--
作者：
ChanJuan Zhang;Yan Zou;Kui Li;Chao Li;YingPing Jiang;Ju Sun;Ruifang Sun;HongMei Wen
促进白色物质可塑性的方法可能促进中风后的功能恢复。研究了不同运动方式对脑卒中大鼠运动功能恢复的影响。然而，目前尚不清楚它们对轴突可塑性的影响是否不同。本研究的目的是比较强迫跑轮运动（RWE）和熟练伸展训练（SRT）对轴突可塑性和运动恢复的影响。在易卒中的肾血管性高血压大鼠中产生皮质梗死。将大鼠随机分为对照组（Con）、RWE组和SRT组。还包括假手术组。分别于缺血后第3、7、14、21、28、35、42天进行mNSS和前肢握力测试。将顺行束示踪剂生物素化葡聚糖胺（BDA）注射到大鼠体内，以追踪对侧离皮质束的轴突可塑性。与Con组相比，SRT组和RWE组mNSS评分在第28天（P < 0.05）、第35天和第42天（P < 0.01）均降低。缺血后42天，SRT组握力较RWE组增加（P < 0.01）。RWE组和SRT组在红核水平和颈膨大水平的离皮质束轴突可塑性均增强（P <0.01）。在红核水平，SRT组对侧皮质红核束重塑明显多于RWE组（P < 0.001）。两者合计，这些结果表明，SRT可以提高皮质红核束的轴突可塑性更有效地比强迫RWE，并与脑缺血后更好的运动恢复。
The approaches that facilitate white matter plasticity may prompt functional recovery after a stroke. The effects of different exercise methods on motor recovery in stroke rats have been investigated. However, it is not clear whether their effects on axonal plasticity different. The aim of this study was to compare the effects of the forced running wheel exercise (RWE) and skilled reaching training (SRT) on axonal plasticity and motor recovery. Cortical infarctions were generated in stroke-prone renovascular hypertensive rats. The rats were randomly divided into the following three groups: the control (Con) group, the RWE group, and the SRT group. A sham group was also included. The mNSS and forelimb grip strength tests were performed on days 3, 7, 14, 21, 28, 35, and 42 after ischemia. The anterograde tract tracer biotinylated dextran amine (BDA) was injected into the rats to trace the axonal plasticity of the contralesional corticofugal tracts. Compared with the Con group, the mNSS scores in the SRT and RWE groups decreased on day 28 (P < 0.05) and on days 35 and 42 (P < 0.01). The grip strength in the SRT group increased relative to that in the RWE group at 42 day post-ischemia (P < 0.01). Both the RWE and SRT groups exhibited enhanced plasticity of the contralesional corticofugal tract axons at the level of the red nucleus (P < 0.01) and the cervical enlargement (P < 0.01). More contralateral corticorubral tract remodeling was observed at the red nucleus level in the SRT group than in the RWE group (P < 0.001). Taken together, these results suggest that SRT may enhance axon plasticity in the corticorubral tract more effectively than the forced RWE and is associated with better motor recovery after cerebral ischemia.
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影响因子：
4.2
作者：
Takenobu, Yohei;Hayashi, Takuya;Moriwaki, Hiroshi;Nagatsuka, Kazuyuki;Naritomi, Hiroaki;Fukuyama, Hidenao
通讯作者：
Fukuyama, Hidenao
影响因子：
6.1
作者：
Benowitz LI;Carmichael ST
通讯作者：
Carmichael ST
影响因子：
8.3
作者：
Zeng, JS;Zhang, YQ;Huang, RX
通讯作者：
Huang, RX
影响因子：
8.3
作者：
Liu Z;Li Y;Zhang X;Savant-Bhonsale S;Chopp M
通讯作者：
Chopp M
影响因子：
6.7
作者：
B. Will;R. Galani;C. Kelche;M. Rosenzweig
通讯作者：
B. Will;R. Galani;C. Kelche;M. Rosenzweig