Bone turnover marker responses to sleep restriction and weekend recovery sleep.
Bone turnover marker responses to sleep restriction and weekend recovery sleep.
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DOI：
10.1016/j.bone.2021.116096
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发表时间：
2021-11
期刊：
影响因子：
4.1
通讯作者：
Swanson CM
中科院分区：
文献类型：
--
作者：
Depner CM;Rice JD;Tussey EJ;Eckel RH;Bergman BC;Higgins JA;Melanson EL;Kohrt WM;Wright KP Jr;Swanson CM
先前的数据显示，三周的睡眠限制和同时存在的昼夜节律紊乱没有偶联的骨转换标志物(BTM)，表明骨形成减少，没有变化或增加骨吸收。睡眠不足加或不加自由周末恢复睡眠对BTMS的影响尚不清楚。在住院实验室环境中，将20名健康成人随机分为三组，其中一组为对照组(N=3人，每晚9小时)，另一组为夜间睡眠限制组。一个睡眠限制组(SR；N=9；4名女性)在9个晚上每晚有5小时的睡眠机会。另一个睡眠限制组在每晚睡眠时间为5小时的4个晚上后，有机会获得自由周末恢复睡眠(WR；N=8；4名女性)。食物摄入量在基线时是能量平衡的，之后是临时的。在研究的第3天(基线)、第5天(在WR和SR限制睡眠1晚后)和第11天(在WR周末恢复睡眠或在SR限制睡眠7晚后)，测定清晨空腹BTM水平和每小时24小时褪黑激素水平。使用线性混合效应模型来检验研究持续时间(例如，随时间的变化)、研究条件、年龄和性别对BTMS的影响。皮尔逊相关性被用来确定BTM的变化与体重变化和早晨昼夜节律失调(即醒来后褪黑激素水平高的持续时间)之间的关系。经年龄和性别调整后，三个研究组之间随时间的变化没有显著差异(分配组之间的交互作用和所有BTM的时间的p≥为0.4%)。从基线到第11天，I型前胶原N端肽(P1NP)、骨钙素和I型胶原C端肽(CTx)无明显变化(均p≥0.3)。在25岁的女性中，从第3天到第5天，P1NP没有显著下降(−15.74±7.80 ng/mL；p=0.06)。从基线到第11天，体重变化和晨间昼夜节律失调与BTM无统计学意义的变化相关(均p≤0.05)。在这个小的二次分析中，我们显示了九个晚上的规定睡眠限制，无论有没有周末恢复睡眠和临时食物摄入，都不会改变BTM。年龄、性别、体重变化和早晨昼夜节律失调可能会改变睡眠限制对骨代谢的影响。
Prior data demonstrated three weeks of sleep restriction and concurrent circadian disruption uncoupled bone turnover markers (BTMs), indicating decreased bone formation and no change or increased bone resorption. The effect of insufficient sleep with or without ad libitum weekend recovery sleep on BTMs is unknown. BTMs were measured in stored serum from 20 healthy adults randomized to one of three study groups consisting of a control group (N = 3 men; 9 h/night) or one of two nocturnal sleep restriction groups in an inpatient laboratory environment. One Sleep Restriction group (“SR”; N = 9; 4 women) had 5h sleep opportunity per night for nine nights. The other sleep restriction group had an opportunity for ad libitum Weekend Recovery sleep (“WR”; N = 8; 4 women) after four nights of 5h sleep opportunity per night. Food intake was energy balanced at baseline and ad libitum thereafter. Fasted morning BTM levels and hourly 24h melatonin levels were obtained on study days 3 (baseline), 5 (after 1 night of sleep restriction for WR and SR), and 11 (after a sleep restricted workweek with weekend recovery sleep in WR or 7 nights of sleep restriction in SR). Linear mixed-effects modeling was used to examine the effect of study duration (e.g., change over time), study condition, age, and sex on BTMs. Pearson correlations were used to determine associations between changes in BTMs and changes in weight and morning circadian misalignment (i.e., duration of high melatonin levels after wake time). There was no significant difference between the three study groups in change over time (p ≥ 0.4 for interaction between assigned group and time for all BTMs), adjusted for age and sex. There was no significant change in N-terminal propeptide of procollagen type I (P1NP), osteocalcin, or C-telopeptide of type I collagen (CTX) from baseline to day 11 (all p ≥ 0.3). In women <25 years old, there was a non-significant decline in P1NP from day 3 to day 5 (−15.74 ± 7.80 ng/mL; p = 0.06). Change in weight and morning circadian misalignment from baseline to day 11 were correlated with statistically non-significant changes in BTMs (all p ≤ 0.05). In this small secondary analysis, we showed that nine nights of prescribed sleep restriction with or without weekend recovery sleep and ad libitum food intake did not alter BTMs. It is possible that age, sex, weight change and morning circadian misalignment modify the effects of sleep restriction on bone metabolism.
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影响因子：
3.7
作者：
Okubo N;Minami Y;Fujiwara H;Umemura Y;Tsuchiya Y;Shirai T;Oda R;Inokawa H;Kubo T;Yagita K
通讯作者：
Yagita K
DOI：
10.1007/s00198-017-4162-5
发表时间：
2017-11
期刊：
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
影响因子：
--
作者：
Swanson C;Shea SA;Wolfe P;Markwardt S;Cain SW;Munch M;Czeisler CA;Orwoll ES;Buxton OM
通讯作者：
Buxton OM
影响因子：
16.2
作者：
Cappuccio FP;D'Elia L;Strazzullo P;Miller MA
通讯作者：
Miller MA
DOI：
10.1073/pnas.1216951110
发表时间：
2013-04-02
影响因子：
11.1
作者：
Markwald, Rachel R.;Melanson, Edward L.;Wright, Kenneth P., Jr.
通讯作者：
Wright, Kenneth P., Jr.
影响因子：
33.9
作者：
Liu, Yong;Wheaton, Anne G.;Croft, Janet B.
通讯作者：
Croft, Janet B.