Abbreviated environmental enrichment confers neurobehavioral, cognitive, and histological benefits in brain-injured female rats.
Abbreviated environmental enrichment confers neurobehavioral, cognitive, and histological benefits in brain-injured female rats.
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DOI：
10.1016/j.expneurol.2016.09.015
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发表时间：
2016-12
影响因子：
5.3
通讯作者：
Kline, Anthony E.
中科院分区：
文献类型：
--
作者：
Radabaugh, Hannah L.;Carlson, Lauren J.;O'Neil, Darik A.;LaPorte, Megan J.;Monaco, Christina M.;Cheng, Jeffrey P.;de la Tremblaye, Patricia B.;Lajud, Naima;Bondi, Corina O.;Kline, Anthony E.
关键词：
环境丰富（EE）促进实验性创伤性脑损伤（TBI）后的行为恢复。然而，实验室提供的慢性康复与物理治疗通常受到限制的诊所不同。此外，女性约占临床TBI人群的40%，但很少在脑外伤中进行研究。因此，本研究的目的是检验简化EE将赋予脑损伤雌性大鼠神经行为、认知和组织学益处的假设。麻醉大鼠接受皮质的影响，中度严重程度（2.8毫米的组织变形，4米/秒）或假损伤，然后随机分配到组接受标准（STD）住房或4小时，6小时，或24小时的EE每天。分别在术后第1-5天和第1-19天每隔一天评估运动功能（平衡木/行走和旋转杆）。在第14-19天评价空间学习/记忆（Morris水迷宫），并在第21天定量皮质损伤体积。在任何评估中，均未发现假手术对照组之间存在统计学差异，因此汇总了数据。所有EE条件均改善了运动功能和记忆保持，但相对于STD，仅6小时和24小时增强了空间学习（p < 0.05）。此外，无论持续时间如何，EE都减少了皮质病变体积（p < 0.05）。这些数据证实，缩短EE赋予强大的神经行为，认知和组织学的好处TBI雌性大鼠，这支持了假设，并加强了EE作为神经康复的临床前模型的效用。
Environmental enrichment (EE) promotes behavioral recovery after experimental traumatic brain injury (TBI). However, the chronic rehabilitation provided in the laboratory is not analogous to the clinic where physiotherapy is typically limited. Moreover, females make up approximately 40% of the clinical TBI population, yet they are seldom studied in brain trauma. Hence, the goal of this study was to test the hypothesis that abbreviated EE would confer neurobehavioral, cognitive, and histological benefits in brain injured female rats. Anesthetized rats received a cortical impact of moderate severity (2.8 mm tissue deformation at 4 m/s) or sham injury and then were randomly assigned to groups receiving standard (STD) housing or 4-hr, 6-hr, or 24-hr of EE daily. Motor function (beam-balance/walk and rotarod) was assessed on post-operative days 1-5 and every other day from 1-19, respectively. Spatial learning/memory (Morris water maze) was evaluated on days 14-19, and cortical lesion volume was quantified on day 21. No statistical differences were appreciated among the sham controls in any assessment and thus the data were pooled. All EE conditions improved motor function and memory retention, but only 6-hr and 24-hr enhanced spatial learning relative to STD (p < 0.05). Moreover, EE, regardless of duration reduced cortical lesion volume (p < 0.05). These data confirm that abbreviated EE confers robust neurobehavioral, cognitive, and histological benefits in TBI female rats, which supports the hypothesis and strengthens the utility of EE as a pre-clinical model of neurorehabilitation.
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影响因子：
4.2
作者：
HAMM, RJ;PIKE, BR;JENKINS, LW
通讯作者：
JENKINS, LW
影响因子：
4.2
作者：
Hamm, RJ;Temple, MD;Lyeth, BG
通讯作者：
Lyeth, BG
影响因子：
4.2
作者：
Cheng, Jeffrey P.;Shaw, Kaitlyn E.;Kline, Anthony E.
通讯作者：
Kline, Anthony E.
影响因子：
56.9
作者：
FEENEY, DM;GONZALEZ, A;LAW, WA
通讯作者：
LAW, WA
影响因子：
3.3
作者：
Chen, X;Li, Y;Wagner, AK
通讯作者：
Wagner, AK