Fatal Interstitial Pneumonia Associated with Bovine Coronavirus in Cows from Southern Italy.
Fatal Interstitial Pneumonia Associated with Bovine Coronavirus in Cows from Southern Italy.
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DOI：
10.3390/v12111331
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发表时间：
2020-11-19
期刊：
影响因子：
--
通讯作者：
Fusco G
中科院分区：
文献类型：
--
作者：
Amoroso MG;Lucifora G;Degli Uberti B;Serra F;De Luca G;Borriello G;De Domenico A;Brandi S;Cuomo MC;Bove F;Riccardi MG;Galiero G;Fusco G
2020年1月，卡拉布里亚地区丘陵地区的一个高产奶牛群爆发了冬季痢疾，并发严重呼吸综合征。在该农场的52只动物中，有5只（9.6%）死于严重呼吸窘迫，死亡发生在出现呼吸体征（呼吸急促）后3-4天。微生物学分析显示没有致病菌，而实时荧光定量PCR鉴定出牛冠状病毒（BCoV） RNA存在于几个器官：肺、小肠（空肠）、纵隔淋巴结、肝脏和胎盘。因此，假设BCoV在致死性肺部感染中起作用。与其他冠状病毒一样，BCoV能够引起不同的综合征。它在犊牛腹泻和轻度呼吸道疾病中的作用是众所周知的：相反，我们报告该病毒参与了一种严重和致命的呼吸道疾病，其症状和疾病演变类似于严重急性呼吸道综合征（SARS）。
An outbreak of winter dysentery, complicated by severe respiratory syndrome, occurred in January 2020 in a high production dairy cow herd located in a hilly area of the Calabria region. Of the 52 animals belonging to the farm, 5 (9.6%) died with severe respiratory distress, death occurring 3–4 days after the appearance of the respiratory signs (caught and gasping breath). Microbiological analysis revealed absence of pathogenic bacteria whilst Real-time PCR identified the presence of RNA from Bovine Coronavirus (BCoV) in several organs: lungs, small intestine (jejunum), mediastinal lymph nodes, liver and placenta. BCoV was therefore hypothesized to play a role in the lethal pulmonary infection. Like the other CoVs, BCoV is able to cause different syndromes. Its role in calf diarrhea and in mild respiratory disease is well known: we report instead the involvement of this virus in a severe and fatal respiratory disorder, with symptoms and disease evolution resembling those of Severe Acute Respiratory Syndromes (SARS).
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影响因子：
3.3
作者：
MCNULTY, MS;BRYSON, DG;LOGAN, EF
通讯作者：
LOGAN, EF
影响因子：
1.5
作者：
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通讯作者：
Reek, Amy
影响因子：
5
作者：
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Decaro, Nicola
影响因子：
3.8
作者：
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通讯作者：
Gorbalenya, AE
影响因子：
10.7
作者：
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通讯作者：
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