I-125 brachytherapy for choroidal melanoma photographic and angiographic abnormalities: the Collaborative Ocular Melanoma Study: COMS Report No. 30.
I-125 brachytherapy for choroidal melanoma photographic and angiographic abnormalities: the Collaborative Ocular Melanoma Study: COMS Report No. 30.
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DOI：
10.1016/j.ophtha.2008.10.013
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发表时间：
2009-01
期刊：
影响因子：
13.7
通讯作者：
Collaborative Ocular Melanoma Study Group
中科院分区：
文献类型：
--
作者：
Boldt HC;Melia BM;Liu JC;Reynolds SM;Collaborative Ocular Melanoma Study Group
(1) 总结用于对参与眼部黑色素瘤合作研究 (COMS) 的患者的眼底照片和荧光素血管造影的放射后异常分级特征的方案； (2) 记录 8 年随访期间这些眼睛后极感兴趣特征的流行情况； (3) 研究与后极特征相关的基线患者、肿瘤和治疗特征。随机、多中心临床试验中的观察性病例系列。我们评估了 650 名被分配到 COMS 并接受碘 125 近距离放射治疗的中型肿瘤患者。在基线和2年、5年和8年时拍摄彩色眼底照片和荧光素血管造影照片；根据标准协议对 30 个功能进行了分级。与视网膜病变和视神经病变相关的眼底照相特征在选定时间间隔的患病率。具有 21 个感兴趣特征的患者比例在基线时为 49.2%，2 年时为 84.4%，5 年时为 91.2%，8 年时为 90.7%。所有随访检查中最常见的发现是黄斑微动脉瘤（75.6％的检查）、黄斑血管造影渗漏（75.1％）和视盘荧光过度（62.8％）。随着每次随访，出现的特征中位数显着增加，在 8 年时达到最多 7 个特征。 5 年时椎间盘新生血管发生率为 5.2%。 5 年视神经病变患病率为 27.4%。更普遍和严重的后极异常的预后因素是糖尿病、肿瘤位置靠近视神经和中心凹无血管区以及对中心凹和视神经乳头的辐射剂量更大。经过 8 年的随访，125 碘近距离放射治疗后视网膜病变和视神经病变的数量和严重程度有所增加。根据标准方案对照片和血管造影进行评估，可以可靠地估计使用 COMS 近距离放射治疗方案治疗的眼睛中视网膜病变和视神经病变特征的发生率。我们的研究结果支持了早期的报道，即除了放射治疗之外，肿瘤因素也可能导致后极异常。
(1) To summarize the protocol used for grading features of postradiation abnormalities from fundus photographs and fluorescein angiograms of patients enrolled in the Collaborative Ocular Melanoma Study (COMS); (2) to document the prevalence of features of interest in the posterior pole of these eyes during 8 years of follow-up; and (3) to investigate baseline patient, tumor, and treatment characteristics associated with posterior pole features. Observational case series within a randomized, multicenter clinical trial. We evaluated 650 patients who were assigned to and received iodine-125 brachytherapy in the COMS for medium-sized tumors. Color fundus photographs and fluorescein angiograms were taken at baseline and 2, 5, and 8 years; 30 features were graded according to a standard protocol. Prevalence at selected time intervals of fundus photographic features associated with retinopathy and optic neuropathy. The percentage of patients with 21 feature of interest was 49.2% at baseline, 84.4% at 2 years, 91.2% at 5 years, and 90.7% at 8 years. The most frequent findings across all follow-up examinations were macular microaneurysms (75.6% of examinations), macular angiographic leakage (75.1%), and optic disc hyperfluorescence (62.8%). The median number of features present increased significantly with each follow-up to a maximum of 7 features at 8 years. The prevalence of neovascularization of the disc at 5 years was 5.2%. The prevalence of optic neuropathy at 5 years was 27.4%. Prognostic factors for more prevalent and severe posterior pole abnormalities were diabetes, tumor location close to both optic nerve and foveal avascular zone, and greater dose of radiation to the foveola and optic nerve head. The amount and severity of retinopathy and optic neuropathy after iodine-125 brachytherapy increased through 8 years of follow-up. Assessment of photographs and angiograms taken in accord with a standard protocol provided reliable estimates of rates of development of features of retinopathy and optic neuropathy in eyes treated using the COMS brachytherapy protocol. Our findings support earlier reports that tumor factors in addition to radiation treatment may contribute to posterior pole abnormalities.
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影响因子：
--
作者：
Kinyoun, JL;Lawrence, BS;Barlow, WE
通讯作者：
Barlow, WE
影响因子：
4.2
作者：
IRVINE, AR;WOOD, IS
通讯作者：
WOOD, IS
DOI：
10.1016/s0360-3016(02)03751-3
发表时间：
2002-12-01
影响因子：
7
作者：
Finger, PT;Berson, A;Szechter, A
通讯作者：
Szechter, A
影响因子：
4.1
作者：
HAYREH, SS
通讯作者：
HAYREH, SS
DOI：
10.1016/s0360-3016(01)02723-7
发表时间：
2002-03-15
影响因子：
7
作者：
Jones, R;Gore, E;Erickson, B
通讯作者：
Erickson, B