Mediating and Moderating Effects of Iron Homeostasis Alterations on Fetal Alcohol-Related Growth and Neurobehavioral Deficits.
Mediating and Moderating Effects of Iron Homeostasis Alterations on Fetal Alcohol-Related Growth and Neurobehavioral Deficits.
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DOI：
10.3390/nu14204432
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发表时间：
2022-10-21
期刊：
影响因子：
5.9
通讯作者：
Jacobson SW
中科院分区：
文献类型：
--
作者：
Carter RC;Dodge NC;Molteno CD;Meintjes EM;Jacobson JL;Jacobson SW
We have previously demonstrated prenatal alcohol exposure (PAE)-related alterations in maternal and infant iron homeostasis. Given that early iron deficiency and PAE both lead to growth restriction and deficits in recognition memory and processing speed, we hypothesized that PAE-related iron homeostasis alterations may mediate and/or moderate effects of PAE on growth and neurobehavior. We examined this hypothesis in a prenatally recruited, prospective longitudinal birth cohort [87 mother-infant pairs with heavy prenatal alcohol exposure (mean = 7.2 drinks/occasion on 1.4 days/week); 71 controls], with serial growth measures and infant neurobehavioral assessments. PAE was related to growth restriction at 2 weeks and 5 years, and, in infancy, poorer visual recognition memory, slower processing speed, lower complexity of symbolic play, and higher emotionality and shyness on a parental report temperament scale. Lower maternal hemoglobin-to-log(ferritin) ratio, which we have shown to be associated with PAE, appeared to exacerbate PAE-related 2-week head circumference reductions, and elevated maternal ferritin, which we have shown to be associated with PAE, appeared to exacerbate PAE-related visual recognition memory deficits. In causal inference analyses, PAE-related elevations in maternal ferritin and hemoglobin:log(ferritin) appeared to statistically mediate 22.6–82.3% of PAE-related growth restriction. These findings support potential mechanistic roles of iron homeostasis alterations in fetal alcohol spectrum disorders (FASD).
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DOI：
10.1111/j.1530-0277.2012.01810.x
发表时间：
2012-11
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Carter RC;Jacobson JL;Molteno CD;Jiang H;Meintjes EM;Jacobson SW;Duggan C
通讯作者：
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DOI：
10.1111/acer.13504
发表时间：
2017-12
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1111/j.1530-0277.1994.tb00041.x
发表时间：
1994-08-01
影响因子：
3.2
作者：
DAY, NL;RICHARDSON, GA;ROBLES, N
通讯作者：
ROBLES, N
影响因子：
8
作者：
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Jacobson, Joseph L.
影响因子：
8
作者：
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