Maternal Alcohol Use and Nutrition During Pregnancy: Diet and Anthropometry.
Maternal Alcohol Use and Nutrition During Pregnancy: Diet and Anthropometry.
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DOI：
10.1111/acer.13504
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发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
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尽管已知产前营养不良的风险和研究记录非怀孕酒精滥用者中不良饮食摄入的流行率增加，但大量饮酒的孕妇的营养状况在很大程度上仍未得到研究。动物模型已经发现产前乙醇暴露与微量营养素（如胆碱，叶酸，B12和铁）之间的相互作用，人类研究报告称，母亲体重和体重降低会增加胎儿酒精相关风险。123名重度饮酒的开普有色孕妇和83名禁欲对照组在首次产前门诊就诊时被招募。在3次产前研究访视时，对每位孕妇进行了关于酒精、吸烟和药物使用的采访，并测量了体重、身高和手臂皮褶。通过三次24小时回忆访谈评估了能量、蛋白质、脂肪和主要微量营养素的膳食摄入量。大多数妇女在怀孕期间体重增加低于推荐的0.42 kg/wk。甲基苯丙胺的使用与二头肌皮褶变小有关，这是身体脂肪的一个指标，而饮酒与任何人体测量指标无关。酒精与较高的磷、胆碱、维生素B12和D摄入量有关。酒精、香烟和甲基苯丙胺的使用与维生素C摄入量降低有关。超过85%的女性报告22种关键营养素中的10种摄入不足，超过50%的女性报告另外3种营养素摄入不足。怀孕期间饮酒与这一人群的饮食或人体测量指标的有意义的变化无关，这表明饮酒者的营养不良不会混淆产前酒精暴露对生长和神经行为的广泛报道的影响。在酒精暴露组和对照组中，妊娠期体重增加不佳和几种营养素摄入不足的比例很高，这也具有公共卫生重要性。
Despite known risks of prenatal nutritional deficiencies and studies documenting increased prevalence of poor dietary intake among nonpregnant alcohol abusers, the nutritional status of heavy drinking pregnant women remains largely unstudied. Animal models have found interactions between prenatal ethanol exposure and micronutrients, such as choline, folate, B12, and iron, and human studies have reported that lower maternal weight and body mass confer increased fetal alcohol-related risk. One hundred and twenty-three heavy drinking Cape Coloured pregnant women and 83 abstaining controls were recruited at their first antenatal clinic visit. At 3 prenatal study visits, each gravida was interviewed about alcohol, smoking, and drug use and weight, height, and arm skinfolds were measured. Dietary intakes of energy, protein, fat, and major micronutrients were assessed from three 24-hour recall interviews. The majority of women gained less than the recommended 0.42 kg/wk during pregnancy. Whereas methamphetamine use was associated with smaller biceps skinfolds, an indicator of body fat, alcohol consumption was not related to any anthropometric indicator. Alcohol was related to higher intake of phosphorus, choline, and vitamins B12 and D. Alcohol, cigarette, and methamphetamine use were related to lower vitamin C intake. Insufficient intake was reported by >85% of women for 10 of 22 key nutrients, and >50% for an additional 3 nutrients. Alcohol consumption during pregnancy was not associated with meaningful changes in diet or anthropometric measures in this population, suggesting that poor nutrition among drinkers does not confound the extensively reported effects of prenatal alcohol exposure on growth and neurobehavior. The poor gestational weight gain and high rates of insufficient intake for several nutrients in both the alcohol-exposed and control groups are also of public health importance.
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DOI：
10.1111/j.1530-0277.2012.01810.x
发表时间：
2012-11
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Carter RC;Jacobson JL;Molteno CD;Jiang H;Meintjes EM;Jacobson SW;Duggan C
通讯作者：
Duggan C
影响因子：
4.8
作者：
Fan, Jia;Jacobson, Sandra W.;Taylor, Paul A.;Molteno, Christopher D.;Dodge, Neil C.;Stanton, Mark E.;Jacobson, Joseph L.;Meintjes, Ernesta M.
通讯作者：
Meintjes, Ernesta M.
影响因子：
8
作者：
Carter, R. Colin;Jacobson, Sandra W.;Jacobson, Joseph L.
通讯作者：
Jacobson, Joseph L.
影响因子：
8
作者：
Hoyme, H. Eugene;Kalberg, Wendy O.;May, Philip A.
通讯作者：
May, Philip A.
影响因子：
3.2
作者：
Henry, CJK
通讯作者：
Henry, CJK