Altered anterior insula activation during anticipation and experience of painful stimuli in expert meditators.
Altered anterior insula activation during anticipation and experience of painful stimuli in expert meditators.
复制标题
DOI：
10.1016/j.neuroimage.2012.09.030
复制
发表时间：
2013-01-01
期刊：
影响因子：
5.7
通讯作者：
Davidson RJ
中科院分区：
文献类型：
--
作者：
Lutz A;McFarlin DR;Perlman DM;Salomons TV;Davidson RJ
从经验上讲，让自己面对痛苦，而不是逃避痛苦，据说会减少头脑中回避或焦虑的倾向，这会进一步加剧痛苦的体验。这是以正念为基础的疗法的中心特征。关于正念对疼痛的神经机制，人们知之甚少。在类似于正念的冥想练习中，专家冥想者(练习10,000小时)使用功能磁共振成像来分离与疼痛、其预期和习惯相关的神经激活模式。与新手相比，专业冥想者报告的疼痛强度相同，但不那么不愉快。对于专家来说，这种差异与疼痛时背侧前脑岛(Ai)和扣带前中央(AMCC)的活动增强有关，也就是所谓的“突出网络”。疼痛时这种增强的活动与疼痛前这些区域和杏仁核的基线活动减少有关，专家只这么认为。左侧Ai的基线激活降低与终生冥想经历相关。这种低基线活动的模式，加上AIN和aMCC的高反应，与疼痛刺激前杏仁核和疼痛相关区域以及疼痛刺激期间疼痛相关区域的神经习惯化增强有关。这些发现表明，培养经验开放性下调了对厌恶事件的预期表征，并增加了疼痛时注意资源的招募，这与更快的神经习惯化有关。
Experientially opening oneself to pain rather than avoiding it is said to reduce the mind’s tendency toward avoidance or anxiety which can further exacerbate the experience of pain. This is a central feature of mindfulness-based therapies. Little is known about the neural mechanisms of mindfulness on pain. During a meditation practice similar to mindfulness, functional magnetic resonance imaging was used in expert meditators (> 10,000 h of practice) to dissociate neural activation patterns associated with pain, its anticipation, and habituation. Compared to novices, expert meditators reported equal pain intensity, but less unpleasantness. This difference was associated with enhanced activity in the dorsal anterior insula (aI), and the anterior mid-cingulate (aMCC) the so-called ‘salience network’, for experts during pain. This enhanced activity during pain was associated with reduced baseline activity before pain in these regions and the amygdala for experts only. The reduced baseline activation in left aI correlated with lifetime meditation experience. This pattern of low baseline activity coupled with high response in aIns and aMCC was associated with enhanced neural habituation in amygdala and pain-related regions before painful stimulation and in the pain-related regions during painful stimulation. These findings suggest that cultivating experiential openness down-regulates anticipatory representation of aversive events, and increases the recruitment of attentional resources during pain, which is associated with faster neural habituation.
登录
查看更多内容
影响因子：
5.9
作者：
Hofmann, Stefan G.;Sawyer, Alice T.;Witt, Ashley A.;Oh, Diana
通讯作者：
Oh, Diana
影响因子：
7.6
作者：
CIOFFI, D;HOLLOWAY, J
通讯作者：
HOLLOWAY, J
影响因子：
3.1
作者：
KABATZINN, J;LIPWORTH, L;BURNEY, R
通讯作者：
BURNEY, R
影响因子：
7.4
作者：
Brown, Christopher A.;Jones, Anthony K. P.
通讯作者：
Jones, Anthony K. P.
影响因子：
2.9
作者：
Hasenkamp W;Barsalou LW
通讯作者：
Barsalou LW