Association of cord blood levels of lead, arsenic, and zinc and home environment with children neurodevelopment at 36 months living in Chitwan Valley, Nepal.
Association of cord blood levels of lead, arsenic, and zinc and home environment with children neurodevelopment at 36 months living in Chitwan Valley, Nepal.
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DOI：
10.1371/journal.pone.0120992
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Watanabe C
中科院分区：
文献类型：
--
作者：
Parajuli RP;Umezaki M;Fujiwara T;Watanabe C
将低水平产前铅暴露与儿童发育联系起来的研究继续报告不一致的结果。由于早期流行病学研究和出生队列随访设计有限，脐带血中有毒元素和必需元素的水平以及产后抚养环境与儿童神经发育的关系在整个童年时期保持不变还是随着时间的推移而变化，仍然没有定论。本研究旨在探讨尼泊尔奇特旺山谷的子宫内有毒物质[铅（Pb）和砷（As）]和必需元素[锌（Zn）]水平对36个月大儿童神经发育的影响，并考虑产后环境。在这项出生队列研究中，参与者（N = 100 对母婴）是在尼泊尔奇旺地区招募的。我们测量了脐带血中的 Pb、As 和 Zn 浓度。使用家庭环境测量观察（HOME）量表评估产后抚养环境（即家庭评分或以下家庭环境）。使用贝利婴儿发育量表第二版 (BSID II) 评估 36 个月大儿童 (n=70) 的神经发育。进行多变量回归（n = 70）以观察子宫内有毒元素和必需元素水平以及家庭环境与针对协变量调整的神经发育评分之间的关联。脐带血中 Pb、As 和 Zn 的水平与 36 个月儿童的任何 BSID II 聚类评分均无关。 HOME 得分和营养状况（36 个月时体重）相对较高的儿童分别表现出比同龄人更好的认知发展（即 MDI 分数）和运动功能。在尼泊尔的一般人群中，产前 Pb、As 和 Zn 水平并不是 36 个月大儿童神经发育的重要决定因素，而刺激的家庭环境对神经发育指标的持续有益影响仍然存在。
Inconsistent results continue to be reported from studies linking low-level prenatal lead exposure and child development. Because of limited earlier epidemiological studies with birth cohort follow up design, it still remains inconclusive that either the associations of cord blood level of toxic, and essential elements, and postnatal raising environment on neurodevelopment of children remains constant throughout childhood or change over time. This study aims to investigate the influence of in utero toxic [lead (Pb) and arsenic (As)] and essential elements [zinc (Zn)] levels on neurodevelopment of 36 months children in Chitwan valley, Nepal taking the postnatal environment into account. In this birth cohort study, participants (N=100 mother-infants’ pairs) were recruited in Chitwan district, Nepal. We measured Pb, As and Zn concentrations in cord blood. Postnatal raising environment (i.e., Home score or home environment hereafter) was evaluated using Home Observation for Measurement of Environment (HOME) scale. Neurodevelopment of children at 36 months of age (n=70) were assessed using Bayley Scale of Infant Development, Second Edition (BSID II). Multivariate regression was performed (n=70) to see the association of in utero toxic and essential elements level and home environment with neurodevelopment score adjusted for covariates. Cord blood levels of Pb, As and Zn were not associated with any BSID II cluster scores of 36 months children. The children with relatively superior HOME score and concurrent nutritional status (weight at 36 months) showed better cognitive development (i.e., MDI scores) and motor functions than their counterparts, respectively. In this general population in Nepal, prenatal Pb, As and Zn levels are not important determinants of the neurodevelopment of 36- month-old children while a consistent beneficial effect of a stimulating home environment on neurodevelopmental indicators is continued.
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DOI：
10.1186/1476-069x-5-31
发表时间：
2006-10-31
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Dakeishi M;Murata K;Grandjean P
通讯作者：
Grandjean P
影响因子：
10.4
作者：
Claus Henn B;Schnaas L;Ettinger AS;Schwartz J;Lamadrid-Figueroa H;Hernández-Avila M;Amarasiriwardena C;Hu H;Bellinger DC;Wright RO;Téllez-Rojo MM
通讯作者：
Téllez-Rojo MM
影响因子：
2.5
作者：
Jedrychowski, Wieslaw;Perera, Frederica;Jankowski, Jeffery;Mrozek-Budzyn, Dorota;Mroz, Elzbieta;Flak, Elzbieta;Edwards, Susan;Skarupa, Anita;Lisowska-Miszczyk, Ilona
通讯作者：
Lisowska-Miszczyk, Ilona
影响因子：
8.3
作者：
Calderón, J;Navarro, ME;Díaz-Barriga, F
通讯作者：
Díaz-Barriga, F
DOI：
10.1007/s004200050248
发表时间：
1998-02-01
影响因子：
3
作者：
Concha, G;Vogler, G;Vahter, M
通讯作者：
Vahter, M