Gut Microbiota: Influence on Carcinogenesis and Modulation Strategies by Drug Delivery Systems to Improve Cancer Therapy.
Gut Microbiota: Influence on Carcinogenesis and Modulation Strategies by Drug Delivery Systems to Improve Cancer Therapy.
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DOI：
10.1002/advs.202003542
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Zhu R;Lang T;Yan W;Zhu X;Huang X;Yin Q;Li Y
肠道微生物群与宿主有着密切的相互作用。它可以影响癌症的进展和癌症治疗的结果，包括化疗，免疫治疗和放疗。因此，调节肠道微生物群的方法将加强癌症的预防和治疗。现代药物递送系统（DDS）正在成为微生物干预的合理和有前途的工具。这些输送系统弥补了与传统治疗相关的障碍。在这篇综述中，首先介绍了肠道微生物群在癌症发生、癌症进展和各种癌症治疗中的重要作用。接下来，重点介绍了DDS的进展，这些进展旨在通过调节或工程化肠道微生物群来增强癌症治疗的疗效。最后，简要讨论了DDS靶向肠道微生物群用于癌症预防和治疗的挑战和机遇。肠道微生物群在癌症发生、癌症进展和癌症治疗中发挥重要作用。现代药物递送系统（DDS）已被开发为用于微生物群调节的合理且有前途的工具。DDS能够克服与传统微生物群调节治疗相关的障碍，并通过提供益生元和益生菌，选择性地消除促肿瘤细菌和捕获细菌产物来有效提高对癌症的治疗效果。
Gut microbiota have close interactions with the host. It can affect cancer progression and the outcomes of cancer therapy, including chemotherapy, immunotherapy, and radiotherapy. Therefore, approaches toward the modulation of gut microbiota will enhance cancer prevention and treatment. Modern drug delivery systems (DDS) are emerging as rational and promising tools for microbiota intervention. These delivery systems have compensated for the obstacles associated with traditional treatments. In this review, the essential roles of gut microbiota in carcinogenesis, cancer progression, and various cancer therapies are first introduced. Next, advances in DDS that are aimed at enhancing the efficacy of cancer therapy by modulating or engineering gut microbiota are highlighted. Finally, the challenges and opportunities associated with the application of DDS targeting gut microbiota for cancer prevention and treatment are briefly discussed. Gut microbiota play essential roles in carcinogenesis, cancer progression, and cancer therapy. Modern drug delivery systems (DDS) have been exploited as rational and promising tools for microbiota modulation. DDS are able to overcome obstacles associated with traditional microbiota‐modulating treatments and efficiently improve therapeutic effects on cancer by delivering prebiotics and probiotics, selectively eliminating pro‐tumoral bacteria, and capturing bacteria products.
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影响因子：
3.9
作者：
Ali, Mohammed S.;Hussein, Rasha M.;Gaber, Yasser;Hammam, Olfat A.;Kandeil, Mohamed A.
通讯作者：
Kandeil, Mohamed A.
来自益生菌和共生大肠杆菌的外膜囊泡可激活肠上皮细胞中 NOD1 介导的免疫反应。
影响因子：
5.2
作者：
Cañas MA;Fábrega MJ;Giménez R;Badia J;Baldomà L
通讯作者：
Baldomà L
DOI：
10.3322/caac.21398
发表时间：
2017-07-08
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Bhatt AP;Redinbo MR;Bultman SJ
通讯作者：
Bultman SJ
影响因子：
64.5
作者：
An D;Oh SF;Olszak T;Neves JF;Avci FY;Erturk-Hasdemir D;Lu X;Zeissig S;Blumberg RS;Kasper DL
通讯作者：
Kasper DL
影响因子：
3.4
作者：
Capitani, Nagaja;Codolo, Gaia;D'Elios, Mario M.
通讯作者：
D'Elios, Mario M.