Functional connectivity: a source of variance in the association between cardiorespiratory fitness and cognition?
Functional connectivity: a source of variance in the association between cardiorespiratory fitness and cognition?
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DOI：
10.1016/j.neuropsychologia.2010.01.005
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发表时间：
2010-04
期刊：
影响因子：
2.6
通讯作者：
Kramer AF
中科院分区：
文献类型：
--
作者：
Voss MW;Erickson KI;Prakash RS;Chaddock L;Malkowski E;Alves H;Kim JS;Morris KS;White SM;Wójcicki TR;Hu L;Szabo A;Klamm E;McAuley E;Kramer AF
在接下来的20年里，被诊断患有痴呆症的美国人的数量预计将增加一倍以上。因此，了解哪些因素有助于健康心灵的长寿是一项重要的公共卫生举措。默认模式网络（DMN）功能和有氧健身的增加都与老年人更好的认知能力和阿尔茨海默病的发病率降低有关。在这里，我们研究有氧健身，在DMN的功能连接，和认知性能之间的关联。结果显示，局部和分布式DMN通路的功能连接存在与年龄相关的显着缺陷。然而，在一组健康的老年人中，几乎一半的年龄相关的断开显示出作为有氧健身水平的函数的功能连接增加。最后，我们研究的假设，DMN的功能连接是有氧健身和认知之间的关系的方差的一个来源。结果表明，具体和全球DMN连接调解健身和认知之间的关系的实例。我们提供了第一个证据的功能连接作为有氧健身和认知之间的关联方差的来源，并讨论结果的背景下，认知衰老和疾病的神经生物学理论。
Over the next twenty years the number of Americans diagnosed with dementia is expected to more than double. It is, therefore, an important public health initiative to understand what factors contribute to the longevity of a healthy mind. Both default mode network (DMN) function and increased aerobic fitness have been associated with better cognitive performance and reduced incidence of Alzheimer’s disease among older adults. Here we examine the association between aerobic fitness, functional connectivity in the DMN, and cognitive performance. Results showed significant age-related deficits in functional connectivity in both local and distributed DMN pathways. However, in a group of healthy elderly adults, almost half of the age-related disconnections showed increased functional connectivity as a function of aerobic fitness level. Finally, we examine the hypothesis that functional connectivity in the DMN is one source of variance in the relationship between aerobic fitness and cognition. Results demonstrate instances of both specific and global DMN connectivity mediating the relationship between fitness and cognition. We provide the first evidence for functional connectivity as a source of variance in the association between aerobic fitness and cognition, and discuss results in the context of neurobiological theories of cognitive aging and disease.
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影响因子：
3.5
作者：
Erickson, Kirk I.;Prakash, Ruchika S.;Voss, Michelle W.;Chaddock, Laura;Hu, Liang;Morris, Katherine S.;White, Siobhan M.;Wojcicki, Thomas R.;McAuley, Edward;Kramer, Arthur F.
通讯作者：
Kramer, Arthur F.
影响因子：
2.1
作者：
Ding, Yun-Hong;Li, Jie;Ding, Yuchuan
通讯作者：
Ding, Yuchuan
影响因子：
3.5
作者：
Clark, Peter J.;Brzezinska, Weronika J.;Puchalski, Emily K.;Krone, David A.;Rhodes, Justin S.
通讯作者：
Rhodes, Justin S.
影响因子：
5.7
作者：
Beckmann, CF;Jenkinson, M;Smith, SM
通讯作者：
Smith, SM
DOI：
10.1098/rstb.2001.0948
发表时间：
2001-09-29
影响因子：
6.3
作者：
Burgess, N;Becker, S;O'Keefe, J
通讯作者：
O'Keefe, J