Plasticity and Susceptibility of Brain Morphometry Alterations to Insufficient Sleep.
Plasticity and Susceptibility of Brain Morphometry Alterations to Insufficient Sleep.
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睡眠不足导致大脑形态变化的可塑性和敏感性
DOI：
10.3389/fpsyt.2018.00266
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发表时间：
2018
影响因子：
4.7
通讯作者：
Zhan Y
中科院分区：
文献类型：
--
作者：
Dai XJ;Jiang J;Zhang Z;Nie X;Liu BX;Pei L;Gong H;Hu J;Lu G;Zhan Y
背景：睡眠不足在日常生活中很常见，可导致认知障碍。睡眠障碍也存在于神经精神疾病中。然而，急性和慢性睡眠缺失是否以及如何影响大脑形态在很大程度上仍然未知。方法：采用基于体素的形态学方法，研究22名健康受试者、39名慢性原发性失眠症患者与39名状态匹配的良好睡眠者在休息清醒、20、24、32、36 h、1晚睡眠后6个时间点睡眠剥夺（SD）期间的脑结构变化。在SD程序的每个SD时间点进行注意网络和空间记忆测试。纵向资料采用单因素重复测量方差分析，并采用事后分析确定组间差异。结果：急性SD与丘脑、小脑、脑岛和顶叶皮层广泛的灰质体积（GMV）变化有关。失眠与颞叶皮层、脑岛和小脑的GMV增加有关。急性SD与脑萎缩有关，随着SD时间的延长，更多的区域显示GMV减少，一晚睡眠后脑萎缩恢复，取而代之的是脑区域GMV增加。SD对注意力和工作记忆有累积的负面影响。结论：急性SD和失眠症表现出明显的GMV形态学改变。SD对大脑形态和高级认知功能有累积的负面影响。GMV的改变可能为睡眠缺失后的注意力和记忆障碍提供了神经生物学基础。与神经和精神疾病相比，成像技术对睡眠的研究较少。急性和慢性睡眠缺失是否以及如何影响大脑形态在很大程度上仍然未知。我们使用基于体素的形态学方法研究了健康受试者在睡眠剥夺（SD）状态和慢性失眠症患者的多个时间点的大脑结构变化。我们发现，延长急性SD伴一晚睡眠恢复表现出脑形态的累积萎缩效应和恢复可塑性，与注意任务的行为改变一致。急性SD和慢性失眠在脑灰质体积（GMV）形态学上有明显的变化，但也有重叠的变化。GMV的改变可能为睡眠缺失后的注意力和记忆障碍提供了结构基础。
Background: Insufficient sleep is common in daily life and can lead to cognitive impairment. Sleep disturbance also exists in neuropsychiatric diseases. However, whether and how acute and chronic sleep loss affect brain morphology remain largely unknown. Methods: We used voxel-based morphology method to study the brain structural changes during sleep deprivation (SD) at six time points of rested wakefulness, 20, 24, 32, 36 h SD, and after one night sleep in 22 healthy subjects, and in 39 patients with chronic primary insomnia relative to 39 status-matched good sleepers. Attention network and spatial memory tests were performed at each SD time point in the SD Procedure. The longitudinal data were analyzed using one-way repeated measures ANOVA, and post-hoc analysis was used to determine the between-group differences. Results: Acute SD is associated with widespread gray matter volume (GMV) changes in the thalamus, cerebellum, insula and parietal cortex. Insomnia is associated with increased GMV in temporal cortex, insula and cerebellum. Acute SD is associated with brain atrophy and as SD hours prolong more areas show reduced GMV, and after one night sleep the brain atrophy is restored and replaced by increased GMV in brain areas. SD has accumulative negative effects on attention and working memory. Conclusions: Acute SD and insomnia exhibit distinct morphological changes of GMV. SD has accumulative negative effects on brain morphology and advanced cognitive function. The altered GMV may provide neurobiological basis for attention and memory impairments following sleep loss. Sleep is less frequently studied using imaging techniques than neurological and psychiatric disorders. Whether and how acute and chronic sleep loss affect brain morphology remain largely unknown. We used voxel-based morphology method to study brain structural changes in healthy subjects over multiple time points during sleep deprivation (SD) status and in patients with chronic insomnia. We found that prolonged acute SD together with one night sleep recovery exhibits accumulative atrophic effect and recovering plasticity on brain morphology, in line with behavioral changes on attentional tasks. Furthermore, acute SD and chronic insomnia exhibit distinct morphological changes of gray matter volume (GMV) but they also share overlapping GMV changes. The altered GMV may provide structural basis for attention and memory impairments following sleep loss.
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影响因子：
3.7
作者：
Elvsåshagen T;Norbom LB;Pedersen PØ;Quraishi SH;Bjørnerud A;Malt UF;Groote IR;Westlye LT
通讯作者：
Westlye LT
影响因子：
5.7
作者：
De Havas, Jack A.;Parimal, Sarayu;Chee, Michael W. L.
通讯作者：
Chee, Michael W. L.
影响因子：
5.6
作者：
Edinger, Jack D.;Means, Melanie K.;Krystal, Andrew D.
通讯作者：
Krystal, Andrew D.
影响因子：
4.8
作者：
Bastien, Celyne H.;Vallieres, Annie;Morin, Charles M.
通讯作者：
Morin, Charles M.
影响因子：
4.4
作者：
Bumb, Jan M.;Schilling, Claudia;Nolte, Ingo
通讯作者：
Nolte, Ingo