Widespread changes in white matter microstructure after a day of waking and sleep deprivation.
Widespread changes in white matter microstructure after a day of waking and sleep deprivation.
复制标题
DOI：
10.1371/journal.pone.0127351
复制
发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Westlye LT
中科院分区：
文献类型：
--
作者：
Elvsåshagen T;Norbom LB;Pedersen PØ;Quraishi SH;Bjørnerud A;Malt UF;Groote IR;Westlye LT
阐明睡眠和清醒的神经生物学效应仍然是神经科学的一个重要目标。最近，动物研究表明，睡眠对大脑中细胞膜和髓鞘的维持很重要，这些结构特别容易受到睡眠不足的影响。在这里，我们测试的假设，即一天的清醒和睡眠剥夺将与扩散张量成像（DTI）指数的变化白色物质的微结构敏感的轴突膜和髓鞘的改变。21名健康成年男性在早晨[7：30 AM;时间点（TP）1]、清醒14小时后（TP 2）和再清醒9小时后（TP 3）进行DTI。使用基于束的空间统计进行全脑体素分析。清醒一天与白色物质分数各向异性的广泛增加有关，这主要是由径向扩散率降低引起的，睡眠剥夺与广泛的分数各向异性降低有关，这主要是由轴向扩散率降低引起的。此外，睡眠剥夺后轴向扩散率的较大下降与更大的困倦有关。所有DTI的变化仍然显着调整后的水合措施。这是第一个关于人类睡眠剥夺的DTI研究。虽然以前的研究已经观察到局部的变化，在几个小时的过程中，大脑微结构的DTI指数，需要进一步的研究，以确认广泛的DTI变化在清醒的几个小时内，并澄清这种变化是否在白色物质微结构作为嗜睡的神经生物学基板。
Elucidating the neurobiological effects of sleep and waking remains an important goal of the neurosciences. Recently, animal studies indicated that sleep is important for cell membrane and myelin maintenance in the brain and that these structures are particularly susceptible to insufficient sleep. Here, we tested the hypothesis that a day of waking and sleep deprivation would be associated with changes in diffusion tensor imaging (DTI) indices of white matter microstructure sensitive to axonal membrane and myelin alterations. Twenty-one healthy adult males underwent DTI in the morning [7:30AM; time point (TP)1], after 14 hours of waking (TP2), and then after another 9 hours of waking (TP3). Whole brain voxel-wise analysis was performed with tract based spatial statistics. A day of waking was associated with widespread increases in white matter fractional anisotropy, which were mainly driven by radial diffusivity reductions, and sleep deprivation was associated with widespread fractional anisotropy decreases, which were mainly explained by reductions in axial diffusivity. In addition, larger decreases in axial diffusivity after sleep deprivation were associated with greater sleepiness. All DTI changes remained significant after adjusting for hydration measures. This is the first DTI study of sleep deprivation in humans. Although previous studies have observed localized changes in DTI indices of cerebral microstructure over the course of a few hours, further studies are needed to confirm widespread DTI changes within hours of waking and to clarify whether such changes in white matter microstructure serve as neurobiological substrates of sleepiness.
登录
查看更多内容
影响因子：
3.7
作者：
Driemeyer J;Boyke J;Gaser C;Büchel C;May A
通讯作者：
May A
影响因子：
5.7
作者：
De Havas, Jack A.;Parimal, Sarayu;Chee, Michael W. L.
通讯作者：
Chee, Michael W. L.
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
10.5
作者：
Cole, James;Chaddock, Christopher A.;Fu, Cynthia H. Y.
通讯作者：
Fu, Cynthia H. Y.
影响因子：
5.7
作者：
Cui, Jiaolong;Tkachenko, Olga;Killgore, William D. S.
通讯作者：
Killgore, William D. S.