Maximizing flow rate in single paper layer, rapid flow microfluidic paper-based analytical devices.

Maximizing flow rate in single paper layer, rapid flow microfluidic paper-based analytical devices.
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DOI:
10.1007/s10404-023-02679-8
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发表时间:
2023
影响因子:
2.8
通讯作者:
--
中科院分区:
工程技术3区
文献类型:
--
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小型单层微流体纸基分析设备(µPADs)为一系列护理点应用提供了潜力;然而,它们仅限于低流量。在这里,我们研究了激光切割纸张通道在有限流体体积的小轮廓装置中最大化流速的作用。我们证明,与单次切割相比,分支激光切割槽可以提供59.23-73.98%的流速提高,比单独切割纸张提高435%。这些设计考虑可以应用于更复杂的微流体装置,目的是增加流量,并可用于独立的自泵通道。在线版本包含补充材料,可在10.1007/s10404-023-02679-8获得。
Small, single-layer microfluidic paper-based analytical devices (µPADs) offer potential for a range of point-of-care applications; however, they have been limited to low flow rates. Here, we investigate the role of laser cutting paper channels in maximizing flow rate in small profile devices with limited fluid volumes. We demonstrate that branching, laser-cut grooves can provide a 59.23–73.98% improvement in flow rate over a single cut, and a 435% increase over paper alone. These design considerations can be applied to more complex microfluidic devices with the aim of increasing the flow rate, and could be used in stand-alone channels for self-pumping. The online version contains supplementary material available at 10.1007/s10404-023-02679-8.
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