Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset.
Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset.
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DOI：
10.1007/s11682-009-9083-2
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发表时间：
2010-03
影响因子：
3.2
通讯作者：
Greenberg, Benjamin D.
中科院分区：
文献类型：
--
作者：
Correia, Stephen;Hubbard, Emily;Hassenstab, Jason;Yip, Agustin;Vymazal, Josef;Herynek, Vit;Giedd, Jay;Murphy, Dennis L.;Greenberg, Benjamin D.
连接额叶皮质和基底神经节(BG)的回路功能障碍与强迫症(OCD)密切相关。在MRI研究中，已知BG病理的神经精神障碍在该区域具有异常短的T2弛豫值(推测是铁升高的生物标志物)。我们询问强迫症患者的血糖T2值是否异常。我们测量了32例强迫症患者和33例正常对照的血糖容量、T2和T1松弛率。尾状核、壳核和苍白球(GP)的体积或T1值没有组间差异。强迫症组右侧GP的T2值较低(提示铁含量较高)，左侧GP的趋势与此相同。这种影响是由强迫症症状从青春期左右到成年早期开始的患者推动的。结果提示，强迫症的发病年龄与基底节的铁沉积可能有关。
Dysfunction in circuits linking frontal cortex and basal ganglia (BG) is strongly implicated in obsessive-compulsive disorder (OCD). On MRI studies, neuropsychiatric disorders with known BG pathology have abnormally short T2 relaxation values (a putative biomarker of elevated iron) in this region. We asked if BG T2 values are abnormal in OCD. We measured volume and T2 and T1 relaxation rates in BG of 32 adults with OCD and 33 matched controls. There were no group differences in volume or T1 values in caudate, putamen, or globus pallidus (GP). The OCD group had lower T2 values (suggesting higher iron content) in the right GP, with a trend in the same direction for the left GP. This effect was driven by patients whose OCD symptoms began from around adolescence to early adulthood. The results suggest a possible relationship between age of OCD onset and iron deposition in the basal ganglia.
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影响因子：
1.3
作者：
Bourekas, EC;Christofoidis, GA;Robitaille, PML
通讯作者：
Robitaille, PML
影响因子：
2.5
作者：
Carmona, Susanna;Bassas, Nuria;Vilarroya, Oscar
通讯作者：
Vilarroya, Oscar
影响因子：
10.6
作者：
BARTZOKIS, G;GARBER, HJ;OLENDORF, WH
通讯作者：
OLENDORF, WH
DOI：
10.1073/pnas.0809449106
发表时间：
2009-02-10
影响因子：
11.1
作者：
Carneiro, Ana M. D.;Airey, David C.;Blakely, Randy D.
通讯作者：
Blakely, Randy D.
影响因子：
2.4
作者：
DRAYER, BP
通讯作者：
DRAYER, BP