The social-emotional processing stream: five core constructs and their translational potential for schizophrenia and beyond.
The social-emotional processing stream: five core constructs and their translational potential for schizophrenia and beyond.
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DOI：
10.1016/j.biopsych.2008.04.024
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发表时间：
2008-07-01
影响因子：
10.6
通讯作者：
Ochsner, Kevin N.
中科院分区：
文献类型：
--
作者：
Ochsner, Kevin N.
关键词：
认知神经科学的转化研究方法在理解功能障碍的基本机制及其与认知缺陷的关系方面取得了重大进展，例如精神分裂症中的思维障碍。最近出现的社会认知和情感神经科学为在解释精神分裂症的社会和情感功能障碍（即阴性症状）的潜在机制方面取得类似进展铺平了道路，这些机制更广泛地描述了几乎所有DSM轴I和II障碍的特征。本文旨在为这项工作提供一个路线图：1)从社会和情感能力的神经基础的新兴文献中提炼出一套关键结构，2)可用于产生关于一般临床功能障碍机制的问题，特别是精神分裂症。为了实现这些目标，本文的第一部分概述了一个包含社会情绪处理流的五个构念的框架。第二部分考虑了未来的基础研究如何充实这个框架，以及转化工作如何将其与精神分裂症和其他临床人群联系起来。尽管这篇综述表明，对每个结构都需要进行更多的基础研究，但有两个特别的结构——一个涉及自下而上地识别社会和情感线索，另一个涉及使用自上而下的过程来得出精神状态推断——最适合用于翻译工作。
Cognitive neuroscience approaches to translational research have made great strides towards understanding basic mechanisms of dysfunction and their relation to cognitive deficits, such as thought disorder in schizophrenia. The recent emergence of Social Cognitive and Affective Neuroscience has paved the way for similar progress to be made in explaining the mechanisms underlying the social and emotional dysfunctions (i.e. negative symptoms) of schizophrenia and that characterize virtually all DSM Axis I and II disorders more broadly. This paper aims to provide a roadmap for this work by 1) distilling from the emerging literature on the neural bases of social and emotional abilities a set of key constructs that 2) can be used to generate questions about the mechanisms of clinical dysfunction in general, and schizophrenia in particular. To achieve these aims, the first part of this paper sketches a framework of five constructs that comprise a social-emotional processing stream. The second part considers how future basic research might flesh out this framework and translational work might relate it to schizophrenia and other clinical populations. Although the review suggests there is more basic research needed for each construct, two in particular – one involving the bottom-up recognition of social and emotional cues, the second involving the use of top-down processes to draw mental state inferences – are most ready for translational work.
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影响因子：
1.7
作者：
Beauregard, Mario;Paquette, Vincent;Levesque, Johanne
通讯作者：
Levesque, Johanne
DOI：
10.1016/s0079-7421(03)01011-9
发表时间：
2003-01-01
期刊：
PSYCHOLOGY OF LEARNING AND MOTIVATION: ADVANCES IN RESEARCH AND THEORY, VOL 43
影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
Cohen, JD
影响因子：
7.6
作者：
Beer, JS;Heerey, EA;Knight, RT
通讯作者：
Knight, RT
DOI：
10.1073/pnas.93.15.8016
发表时间：
1996-07-23
影响因子：
11.1
作者：
Cahill, L;Haier, RJ;McGaugh, JL
通讯作者：
McGaugh, JL