Longitudinal changes in cortical thickness associated with normal aging.
Longitudinal changes in cortical thickness associated with normal aging.
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DOI：
10.1016/j.neuroimage.2010.04.258
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发表时间：
2010-10-01
期刊：
影响因子：
5.7
通讯作者：
Resnick, Susan M.
中科院分区：
文献类型：
--
作者：
Thambisetty, Madhav;Wan, Jing;Carass, Aaron;An, Yang;Prince, Jerry L.;Resnick, Susan M.
区域性灰质体积和皮质厚度解剖变化的成像研究已经证明了许多大脑区域的年龄影响，但大多数此类研究都是在单个时间点对个体进行的横断面调查。在这项研究中，通过对巴尔的摩衰老纵向研究（BLSA）参与者的连续成像评估，我们研究了66名老年人（平均年龄68.78;sd）在衰老过程中皮质厚度的纵向变化。6.6;范围60-84（基线），无痴呆。我们使用皮质重建使用隐式表面进化巡航套件算法来自动生成皮质表面的重建，并识别每个半球20个感兴趣的基于回转体的区域。使用混合效应回归，我们调查了这些区域在平均8年随访期间的纵向变化。本研究的主要发现是，与年龄相关的皮质厚度下降是普遍存在的，但在额叶和顶叶区域表现出一种前后梯度，总体上表现出比颞叶和枕叶更大的下降率。在右半球中有较少的区域显示出具有统计学意义的与年龄相关的平均皮质厚度纵向下降。男性在左半球、右楔前叶、前额叶中部、下顶叶、海马旁、中央后和颞上回以及双侧的上顶叶和扣带区表现出更大的下降率。随着时间的推移，左侧的中央后回、中央前回和眶额回以及右侧的顶叶下回、扣带回和眶额回发生了显著的非线性变化。
Imaging studies of anatomic changes in regional gray matter volumes and cortical thickness have documented age effects in many brain regions, but the majority of such studies have been cross-sectional investigations of individuals studied at a single point in time. In this study, using serial imaging assessments of participants in the Baltimore Longitudinal Study of Aging (BLSA), we investigate longitudinal changes in cortical thickness during aging in a cohort of 66 older adults (mean age 68.78; sd. 6.6; range 60-84 at baseline) without dementia. We used the Cortical Reconstruction Using Implicit Surface Evolution CRUISE suite of algorithms to automatically generate a reconstruction of the cortical surface and identify twenty gyral based regions of interest per hemisphere. Using mixed effects regression, we investigated longitudinal changes in these regions over a mean follow-up interval of 8 years. The main finding in this study is that age-related decline in cortical thickness is widespread, but shows an anterior-posterior gradient with frontal and parietal regions, in general, exhibiting greater rates of decline than temporal and occipital. There were fewer regions in the right hemisphere showing statistically significant age-associated longitudinal decreases in mean cortical thickness. Males showed greater rates of decline in the middle frontal, inferior parietal, parahippocampal, postcentral, and superior temporal gyri in the left hemisphere, right precuneus and bilaterally in the superior parietal and cingulate regions. Significant nonlinear changes over time were observed in the postcentral, precentral, and orbitofrontal gyri on the left and inferior parietal, cingulate, and orbitofrontal gyri on the right.
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3.7
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