Choroidal thickness measured by spectral domain optical coherence tomography: factors affecting thickness in glaucoma patients.
Choroidal thickness measured by spectral domain optical coherence tomography: factors affecting thickness in glaucoma patients.
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DOI：
10.1016/j.ophtha.2011.01.016
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发表时间：
2011-08
期刊：
影响因子：
13.7
通讯作者：
Quigley HA
中科院分区：
文献类型：
--
作者：
Maul EA;Friedman DS;Chang DS;Boland MV;Ramulu PY;Jampel HD;Quigley HA
测量脉络膜厚度并确定相关参数。横断面研究。74例青光眼患者和青光眼疑似患者。光谱域光学相干断层扫描（SDOCT）扫描获得估计平均脉络膜厚度在一组青光眼嫌疑人和青光眼患者。根据增强深度SDOCT图像计算平均厚度，并用Image J软件手动分析。开角型青光眼、可疑开角型青光眼、原发性闭角型青光眼、原发性闭角型青光眼和可疑原发性闭角型青光眼均按已发表的标准定义。疑似青光眼患者双侧视野正常。青光眼的定义是视神经盘损伤和至少一只眼睛的视野丧失的特定标准。对受影响最严重的眼睛进行分析，以进行个体间的比较，同时进行右/左和上半部分/下半部分比较，以比较厚度与视野损伤程度。使用SDOCT测量平均黄斑和视乳头周围脉络膜厚度。脉络膜-巩膜界面（CSI）分别在86%和96%的黄斑和视乳头周围扫描中可见。在多元线性回归分析中，黄斑脉络膜明显变薄与4个特征相关：（22 µm/mm长[95%置信区间（CI）：−33，−11]），老年人（年龄每增加10岁，厚度减少31 µm [95% CI：−44 −17]），舒张期眼灌注压降低（每降低10 mmHg，厚度减少26 µm [95% CI：8，44]）和中央角膜厚度增加（每增加10 µm，厚度增加6 µm [95% CI：-10，0]）。青光眼患者的脉络膜并不比可疑青光眼患者明显薄（14 µm [95% CI：-54，26]，p=0.5）。青光眼和可疑患者的视盘周围脉络膜厚度无显著差异。通过视野平均偏差或神经纤维层厚度（包括右眼与左眼或上限值与下限值的比较）估计，厚度与损伤严重程度无关。年龄、眼轴长度、中央角膜厚度和舒张期眼灌注压与青光眼可疑者和青光眼患者的脉络膜厚度显著相关。青光眼损害的程度与脉络膜厚度并不一致。
To measure choroidal thickness and to determine parameters associated with it. Cross-sectional study. Seventy-four glaucoma patients and glaucoma suspects. Spectral domain optical coherence tomography (SDOCT) scans were obtained to estimate average choroidal thickness in a group of glaucoma suspects and glaucoma patients. Average thickness was calculated from enhanced depth SDOCT images and manually analyzed with Image J software. Open angle glaucoma, open angle glaucoma suspect, primary angle closure glaucoma, primary angle closure, and primary angle closure suspect were defined by published criteria. Glaucoma suspects had normal visual fields bilaterally. Glaucoma was defined by specific criteria for optic disc damage and visual field loss in at least one eye. The most affected eye was analyzed for comparisons across individuals, while right/left and upper half/lower half comparisons were made to compare thickness against degree of visual field damage. Average macular and peripapillary choroidal thickness measured using SDOCT. The choroidal-scleral interface (CSI) was visualized in 86% and 96% of the macular and peripapillary scans, respectively. In multivariable linear regression analysis, the macular choroid was significantly thinner in association with 4 features: longer eyes (22 µm per mm longer [95% confidence Interval (CI): −33, −11]), older individuals (31 µm thinner per decade older [95% CI: −44 −17]), lower diastolic ocular perfusion pressure (26 µm thinner per 10 mmHg lower [95% CI: 8, 44]), and thicker central corneas (6 µm per 10 µm thicker cornea [95% CI: −10, 0]). The choroid was not significantly thinner in glaucoma patients than in suspects (14 µm [95% CI: −54, 26], p=0.5). Peripapillary choroidal thickness was not significantly different between glaucomaand suspect patients. Thickness was not associated with damage severity as estimated by visual field mean deviation or nerve fiber layer thickness, including comparisons of right to left eye or upper to lower values. Age, axial length, central corneal thickness, and diastolic ocular perfusion pressure are significantly associated with choroidal thickness in glaucoma suspects and glaucoma patients. Degree of glaucoma damage was not consistently associated with choroidal thickness.
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影响因子：
4.4
作者：
Ikuno, Yasushi;Kawaguchi, Kana;Yasuno, Yoshiaki
通讯作者：
Yasuno, Yoshiaki
影响因子：
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作者：
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通讯作者：
AKAIKE, H