Predictive 3D modelling of the interactions of pyrethroids with the voltage-gated sodium channels of ticks and mites.
Predictive 3D modelling of the interactions of pyrethroids with the voltage-gated sodium channels of ticks and mites.
复制标题
拟除虫菊酯与蜱和螨的电压门控钠通道相互作用的预测 3D 建模。
DOI：
10.1002/ps.3561
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发表时间：
2014
影响因子：
4.1
通讯作者：
O'Reilly AO
中科院分区：
文献类型：
--
作者：
O'Reilly AO
背景拟除虫菊酯类杀虫剂是一组非常成功的化合物，靶向无脊椎动物电压门控钠通道，广泛用于控制昆虫、蜱和螨。已经确定，一些拟除虫菊酯是良好的杀虫剂，而另一些拟除虫菊酯作为杀螨剂更有效。这种物种特异性有利于在另一种非靶标无脊椎动物存在的情况下控制特定害虫，例如控制蜂群中的瓦螨。我们应用计算机技术比较昆虫和螨的电压门控钠通道及其与一系列拟除虫菊酯和滴滴涕类似物的相互作用。我们在蜱/螨的拟除虫菊酯结合口袋中发现了一个氨基酸差异，这可能对拟除虫菊酯作为杀螨剂的有效性产生重大影响。在不同的蜱和螨物种的结合口袋内的其他个别氨基酸的差异可能提供了一个基础，为未来的杀螨selectivity.CONCLUSIONSThree-dimensional建模的拟除虫菊酯/DDT受体网站导致了一个新的假说来解释优先结合的杀螨拟除虫菊酯的钠通道的蜱/螨。这对于了解拟除虫菊酯的选择性和突变的潜在影响非常重要，这些突变可能导致具有商业重要性的害虫物种对拟除虫菊酯产生抗性。© 2013化学工业协会
BACKGROUNDThe pyrethroid insecticides are a very successful group of compounds that target invertebrate voltage‐gated sodium channels and are widely used in the control of insects, ticks and mites. It is well established that some pyrethroids are good insecticides whereas others are more effective as acaricides. This species specificity is advantageous for controlling particular pest(s) in the presence of another non‐target invertebrate, for example controlling the Varroa mite in honeybee colonies.RESULTSWe appliedin silicotechniques to compare the voltage‐gated sodium channels of insectsversusticks and mites and their interactions with a range of pyrethroids and DDT analogues. We identified a single amino acid difference within the pyrethroid binding pocket of ticks/mites that may have significant impact on the effectiveness of pyrethroids as acaricides. Other individual amino acid differences within the binding pocket in distinct tick and mite species may provide a basis for future acaricidal selectivity.CONCLUSIONSThree–dimensional modelling of the pyrethroid/DDT receptor site has led to a new hypothesis to explain the preferential binding of acaricidal pyrethroids to the sodium channels of ticks/mites. This is important for understanding pyrethroid selectivity and the potential effects of mutations that can give rise to resistance to pyrethroids in commercially‐important pest species. © 2013 Society of Chemical Industry
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影响因子：
64.8
作者：
Long, Stephen B.;Tao, Xiao;MacKinnon, Roderick
通讯作者：
MacKinnon, Roderick
影响因子：
4.1
作者：
Nyoni, Benjamin N.;Gorman, Kevin;Bass, Chris
通讯作者：
Bass, Chris
影响因子：
4
作者：
Jonsson, N. N.;Cutulle, C.;Seddon, J. M.
通讯作者：
Seddon, J. M.
影响因子：
4
作者：
Morgan, Jess A. T.;Corley, Sean W.;Jonsson, Nicholas N.
通讯作者：
Jonsson, Nicholas N.
关于新兴媒介传播人畜共患病的公共卫生政策和风险评估的生态方法。
DOI：
10.3134/ehtj.10.001
发表时间：
2010
期刊：
Emerging health threats journal
影响因子：
--
作者：
Medlock J;Jameson Lj
通讯作者：
Jameson Lj