Association between serum manganese and serum klotho in a 40-80-year-old American population from NHANES 2011-2016.
Association between serum manganese and serum klotho in a 40-80-year-old American population from NHANES 2011-2016.
复制标题
DOI：
10.3389/fragi.2023.1120823
复制
发表时间：
2023
影响因子：
--
通讯作者：
Wang, Jun
中科院分区：
文献类型：
--
作者：
Guan, Guoyu;Cai, Jiasheng;Zheng, Songbai;Xiang, Yanzhen;Xia, Shijin;Zhang, Yixuan;Shi, Jiaqiang;Wang, Jun
目的：锰是人体必需的微量元素之一。Klotho蛋白是一种经典的抗衰老标志物。在美国，40-80岁人群中血清锰和血清klotho水平之间的关系尚不清楚。 研究方法：这项横断面研究的数据来自美国国家健康和营养调查（NHANES 2011-2016）。我们进行了多元线性回归分析，以探讨血清锰和血清klotho水平之间的关联。此外，我们进行了拟合光滑曲线，根据一个限制三次样条（RCS）。进行分层和亚组分析以进一步验证结果。 结果如下：多元线性回归分析显示，血清锰水平与血清klotho水平呈独立正相关（β = 6.30，95%可信区间：3.30-9.40）。Kruskal-Wallis检验显示，锰四分位数较高的参与者血清klotho水平较高（Q1：808.54 ± 256.39 pg/mL; Q2：854.56 ± 266.13 pg/mL; Q3：865.13 ± 300.60 pg/mL; Q4：871.72 ± 338.85 pg/mL，p < 0.001）。RCS曲线显示血清锰与血清klotho呈非线性关系。此外，在大多数亚组中，血清锰和血清klotho水平之间存在显著正相关。 结论：根据NHANES（2011-2016），在美国40-80岁的个体中发现血清锰和血清klotho水平之间存在非线性和正相关。
Objectives: Manganese is one of the essential trace elements that are required by the human body. Klotho protein is a classic anti-aging marker. The association between the levels of serum manganese and serum klotho in individuals between the ages of 40–80 in the United States remains unclear. Methods: Data for this cross-sectional study was obtained from the National Health and Nutrition Examination Survey (NHANES 2011–2016) in the United States. We performed multiple linear regression analyses to investigate the association between the levels of serum manganese and serum klotho. Furthermore, we performed a fitted smoothing curve according to a restricted cubic spline (RCS). Stratification and subgroup analyses were performed for further verification of the results. Results: Weighted multivariate linear regression analysis showed that serum manganese levels were independently and positively associated with serum klotho levels (β = 6.30, 95% confidence interval: 3.30–9.40). Kruskal–Wallis test showed that participants with higher manganese quartiles had higher serum klotho levels (Q1: 808.54 ± 256.39 pg/mL; Q2: 854.56 ± 266.13 pg/mL; Q3: 865.13 ± 300.60 pg/mL; and Q4: 871.72 ± 338.85 pg/mL, p < 0.001). The RCS curve indicated that the association between the levels of serum manganese and serum klotho was non-linear. Furthermore, a significantly positive association was found between serum manganese and serum klotho levels in the majority of subgroups. Conclusion: A non-linear and positive association was found between the levels of serum manganese and serum klotho in individuals aged 40–80 in the United States according to the NHANES (2011–2016).
登录
查看更多内容
影响因子：
20.1
作者：
Chen K;Wang S;Sun QW;Zhang B;Ullah M;Sun Z
通讯作者：
Sun Z
影响因子：
18.2
作者：
Hu MC;Shiizaki K;Kuro-o M;Moe OW
通讯作者：
Moe OW
影响因子：
3.5
作者：
Cai, Jiasheng;Zhang, Lingyun;Song, Bin
通讯作者：
Song, Bin
影响因子：
56.9
作者：
Kurosu, H;Yamamoto, M;Kuro-o, M
通讯作者：
Kuro-o, M
影响因子：
3
作者：
Nie, Fang;Wu, Dongming;Xu, Ying
通讯作者：
Xu, Ying