Correlation between Antistress and Hepatoprotective Effects of Schisandra Lignans Was Related with Its Antioxidative Actions in Liver Cells.
Correlation between Antistress and Hepatoprotective Effects of Schisandra Lignans Was Related with Its Antioxidative Actions in Liver Cells.
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DOI：
10.1155/2012/161062
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Kurihara H
中科院分区：
文献类型：
--
作者：
Pu HJ;Cao YF;He RR;Zhao ZL;Song JH;Jiang B;Huang T;Tang SH;Lu JM;Kurihara H
本研究旨在探讨五味子木脂素提取物（SLE）对应激性肝损伤的抗应激和保肝作用之间的关系。将7周龄雄性小鼠固定在束缚管中18 h以诱导肝损伤。在暴露于束缚应激之前，以100和200 mg/kg/天的剂量对动物经口给予SLE 5天。口服SLE可显著减轻实验动物的束缚性肝损伤。进一步发现SLE显著减轻应激小鼠中皮质酮的激发。SLE还通过防止自由基的过度产生和积累，显著降低氧化损伤并提高肝细胞的抗氧化能力。总之，证实了SLE对应激性肝损伤的保护作用，并且五味子木脂素的保肝和抗应激作用之间的相关性可能与其减轻应激因素对生物稳态的恶性影响有关，例如细胞中氧化和还原的平衡。
The present study was conducted to investigate the relationship between the anti-stress and hepato-protective effects of Schisandra Lignans Extract (SLE) on stress-induced liver damage. Seven weeks old male mice were fixed in a restraint tube for 18 h to induce liver damage. SLE was orally administered to animals for 5 days at dosages of 100 and 200 mg/kg/day before exposed to restraint stress. Oral administration of SLE significantly reduced restraint-induced liver damage in experimental animal. SLE was further found to significantly alleviate the provocation of corticosterone in stressed mice. SLE also significantly decreased oxidative damage and increased anti-oxidative capability of liver cells by preventing the over production and accumulation of free radicals. In conclusion, the protective effects of SLE on stress-induced liver damage were confirmed, and the correlation between hepatoprotective and anti-stress effects of schisandra lignans was possible related to its alleviation on the malignant effects of stressors for bio-homeostasis, such as balance of oxidation and reduction in cells.
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影响因子：
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作者：
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影响因子：
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