Similar brain activation during false belief tasks in a large sample of adults with and without autism.
Similar brain activation during false belief tasks in a large sample of adults with and without autism.
复制标题
DOI：
10.1371/journal.pone.0075468
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Saxe R
中科院分区：
文献类型：
--
作者：
Dufour N;Redcay E;Young L;Mavros PL;Moran JM;Triantafyllou C;Gabrieli JD;Saxe R
阅读另一个人的信仰涉及“心智理论”过程，并在个体和实验范式中引发高度可靠的大脑激活。利用功能性磁共振成像技术，我们在一个大样本的神经正常个体（N = 462）和一组患有自闭症谱系障碍的高功能个体（N = 31）中，使用兴趣区和全脑分析，检查了故事任务期间的激活情况，该任务旨在引发心理理论的处理。这么大的样本使我们能够研究大脑在异常高灵敏度的心智理论任务中激活的组间差异。在神经正常的参与者和被诊断为自闭症谱系障碍的参与者之间没有差异。这些结果表明，典型的自闭症谱系障碍的社会认知障碍可以在成年人执行外显心智理论任务时，在活动的大小、位置或反应幅度上没有可测量的变化。
Reading about another person’s beliefs engages ‘Theory of Mind’ processes and elicits highly reliable brain activation across individuals and experimental paradigms. Using functional magnetic resonance imaging, we examined activation during a story task designed to elicit Theory of Mind processing in a very large sample of neurotypical (N = 462) individuals, and a group of high-functioning individuals with autism spectrum disorders (N = 31), using both region-of-interest and whole-brain analyses. This large sample allowed us to investigate group differences in brain activation to Theory of Mind tasks with unusually high sensitivity. There were no differences between neurotypical participants and those diagnosed with autism spectrum disorder. These results imply that the social cognitive impairments typical of autism spectrum disorder can occur without measurable changes in the size, location or response magnitude of activity during explicit Theory of Mind tasks administered to adults.
登录
查看更多内容
影响因子：
4.2
作者：
Dichter, Gabriel S.;Felder, Jennifer N.;Bodfish, James W.
通讯作者：
Bodfish, James W.
影响因子：
3.2
作者：
Adolphs, R;Sears, L;Piven, J
通讯作者：
Piven, J
影响因子：
5.7
作者：
Lombardo, Michael V.;Chakrabarti, Bhismadev;Baron-Cohen, Simon
通讯作者：
Baron-Cohen, Simon
影响因子：
2.6
作者：
Kliemann, Dorit;Young, Liane;Saxe, Rebecca
通讯作者：
Saxe, Rebecca
影响因子：
7.6
作者：
Baron-Cohen, S;Wheelwright, S;Plumb, I
通讯作者：
Plumb, I