Nicotine delivery and user reactions to Juul EU (20 mg/ml) compared with Juul US (59 mg/ml), cigarettes and other e-cigarette products.
Nicotine delivery and user reactions to Juul EU (20 mg/ml) compared with Juul US (59 mg/ml), cigarettes and other e-cigarette products.
复制标题
DOI：
10.1007/s00213-020-05734-2
复制
发表时间：
2021-03
影响因子：
3.4
通讯作者：
Hajek P
中科院分区：
文献类型：
--
作者：
Phillips-Waller A;Przulj D;Smith KM;Pesola F;Hajek P
含20 mg/ml尼古丁的欧盟版Juul（Juul EU）向使用者提供尼古丁的程度可能决定其治疗潜力。比较Juul EU、Juul US（59 mg/ml尼古丁）、香烟和其他电子烟（EC）产品的药代动力学特征和用户评级。在一项受试者内交叉设计中，18名vapers在单独的会议上使用自己的品牌香烟（OBC），Juul US和Juul EU，在过夜禁欲后自由吸烟5分钟。其中七名参与者之前还测试了其他八名EC。在基线和开始使用产品后2、4、6、8、10和30 min采集血样。产品根据一系列特性进行评级。Juul EU的尼古丁释放量低于OBC（t（13）= −4.64 p < .001）和Juul US（t（13）= −6.40，p < .001）：AUC 0 ≥ 30分别为77.3、324.8和355.9。Juul EU的最大尼古丁浓度（Cmax）也远低于Juul US（z = −3.59，p < .001）：Cmax分别为3.8 ng/ml vs 21.1 ng/ml。Juul EU被认为比Juul US（z =-2.29，p = 0.022）更少地缓解吸烟欲望，并提供更少的尼古丁（z =-2.57）。p = 0.010）。Juul EU的尼古丁含量低于可再填充EC（Cmax：t（6）= 3.02，p = 0.023; AUC 0 ≥ 30：z =-2.20，p = 0.028），也低于类烟EC，但差异未达到显著性（Cmax：t（6）= 2.49，p = 0.047; AUC 0 ≥ 30：z = −1.99，p = 0.046）。Juul EU和其他EC产品的主观评级相似。Juul EU向用户提供的尼古丁比Juul US少得多，也比可再填充的EC产品少。因此，它在帮助吸烟者戒烟方面的潜力可能更有限。
The degree to which the EU version of Juul with 20 mg/ml nicotine (Juul EU) delivers nicotine to users is likely to determine its treatment potential. To compare the pharmacokinetic profile and user ratings of Juul EU, Juul US (59 mg/ml nicotine), cigarettes and other e-cigarette (EC) products. In a within-subjects crossover design, 18 vapers used, at separate sessions, their own brand cigarette (OBC), Juul US and Juul EU for 5 min ad libitum, after overnight abstinence. Seven of the participants also tested eight other EC previously. Blood samples were taken at baseline and 2, 4, 6, 8, 10 and 30 min after initiating product use. Products were rated on a range of characteristics. Juul EU delivered less nicotine than OBC (t(13) = −4.64 p < .001) and than Juul US (t(13) = −6.40, p < .001): AUC0 ≥ 30 77.3, 324.8 and 355.9, respectively. Maximum nicotine concentration (Cmax) was also much lower for Juul EU than Juul US (z = −3.59, p < .001): Cmax 3.8 ng/ml vs 21.1 ng/ml, respectively. Juul EU was perceived to relieve urges to smoke less than Juul US (z = −2.29, p = .022) and to provide less nicotine (z = −2.57. p = 0.010). Juul EU delivered less nicotine than refillable EC (Cmax: t(6) = 3.02, p = 0.023; AUC0 ≥ 30: z = −2.20, p = 0.028) and also less than cig-a-like EC, though the difference did not reach significance (Cmax: t(6) = 2.49, p = 0.047; AUC0 ≥ 30: z = −1.99, p = 0.046). Subjective ratings of Juul EU and other EC products were similar. Juul EU delivers much less nicotine to users than Juul US, and also less than refillable EC products. It may thus have more limited potential to help smokers quit.
登录
查看更多内容
影响因子：
6
作者：
Hajek, Peter;Pittaccio, Kate;Przulj, Dunja
通讯作者：
Przulj, Dunja
影响因子：
4.6
作者：
Talih, Soha;Salman, Rola;Shihadeh, Alan
通讯作者：
Shihadeh, Alan
影响因子：
3.4
作者：
Hajek, Peter;Przulj, Dunja;McRobbie, Hayden
通讯作者：
McRobbie, Hayden
影响因子：
4.4
作者：
Soar, K.;Kimber, C.;Dawkins, L. E.
通讯作者：
Dawkins, L. E.
影响因子：
3.4
作者：
Hajek, Peter;Przulj, Dunja;McRobbie, Hayden
通讯作者：
McRobbie, Hayden