Dopaminergic therapy in Parkinson's disease decreases cortical beta band coherence in the resting state and increases cortical beta band power during executive control.
Dopaminergic therapy in Parkinson's disease decreases cortical beta band coherence in the resting state and increases cortical beta band power during executive control.
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DOI：
10.1016/j.nicl.2013.07.013
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Aron AR
中科院分区：
文献类型：
--
作者：
George JS;Strunk J;Mak-McCully R;Houser M;Poizner H;Aron AR
多巴胺能治疗如何改善帕金森病（PD）的认知和运动功能尚不清楚。一种可能是它减少了皮层和基底神经节内部和之间的病理同步，从而改善了神经通讯。我们通过记录PD患者的头皮脑电图（EEG）来验证这一假设，这些患者分别在开药和关药、短暂的静息状态时期（无任务）和执行被认为涉及两个部分重叠（或不同）的额基底神经节回路的停止信号任务期间。对于静息状态脑电图，我们测量了几个频段头皮电极之间的成对相干性。与既往研究一致，在Off给药状态下，临床损害最大的患者相干性最强，尤其是β带，表明病理性过度同步。多巴胺能药物降低了这种一致性。对于停止信号任务，开与关药物增加了右侧额叶皮层的β带功率，成功停止和双侧感觉运动皮层的β带功率，特别是对那些表现出更大临床改善的患者。因此，药物降低了休息时β带的病理一致性，并增加了两个潜在可分离的皮质-基底神经节回路的任务相关β功率。这些结果支持了PD患者多巴胺能药物治疗在休息时改善神经通讯以及执行和运动功能的假设。在休息和执行控制任务时，在开/关药物时测量PD的脑电图。多巴胺能治疗减少病理性锁定与临床改善。药物会在右额叶皮层成功停止时增加β能量。
It is not yet well understood how dopaminergic therapy improves cognitive and motor function in Parkinson's disease (PD). One possibility is that it reduces the pathological synchronization within and between the cortex and basal ganglia, thus improving neural communication. We tested this hypothesis by recording scalp electroencephalography (EEG) in PD patients when On and Off medication, during a brief resting state epoch (no task), and during performance of a stop signal task that is thought to engage two partially overlapping (or different) frontal-basal-ganglia circuits. For resting state EEG, we measured pair-wise coherence between scalp electrodes in several frequency bands. Consistent with previous studies, in the Off medication state, those patients with the greatest clinical impairment had the strongest coherence, especially in the beta band, indicating pathological over-synchronization. Dopaminergic medication reduced this coherence. For the stop signal task, On vs. Off medication increased beta band power over right frontal cortex for successful stopping and over bilateral sensorimotor cortex for going, especially for those patients who showed greater clinical improvement. Thus, medication reduced pathological coherence in beta band at rest and increased task related beta power for two potentially dissociable cortico-basal ganglia circuits. These results support the hypothesis that dopaminergic medication in PD improves neural communication both at rest and for executive and motor function. EEG measured in PD while On/Off medication during rest and an executive control task. Dopaminergic therapy reduces pathological locking jointly with clinical improvement. Medication increases beta power during successful stopping over right frontal cortex.
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影响因子：
3.2
作者：
Kraemer, Ulrike M.;Knight, Robert T.;Muente, Thomas F.
通讯作者：
Muente, Thomas F.
影响因子：
5.3
作者：
Aron, Adam R.;Behrens, Tim E.;Poldrack, Russell A.
通讯作者：
Poldrack, Russell A.
DOI：
10.1126/science.1167093
发表时间：
2009-04-17
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gradinaru V;Mogri M;Thompson KR;Henderson JM;Deisseroth K
通讯作者：
Deisseroth K
影响因子：
6.9
作者：
Chikazoe, Junichi
通讯作者：
Chikazoe, Junichi
影响因子：
9.9
作者：
HOEHN, MM;YAHR, MD
通讯作者：
YAHR, MD