Similarities in the Age-Specific Incidence of Colon and Testicular Cancers.
Similarities in the Age-Specific Incidence of Colon and Testicular Cancers.
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DOI：
10.1371/journal.pone.0066694
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Brody JP
中科院分区：
文献类型：
--
作者：
Soto-Ortiz L;Brody JP
结肠癌被认为是衰老的必然结果，而睾丸癌被认为只在一小部分男性中发生，从子宫内开始。这些致癌模型部分是基于年龄特异性发病率数据。结肠癌的具体发病率似乎随着年龄的增长而单调增加，而睾丸癌的发病率在35岁左右增加到最大值，然后在80岁时下降到几乎为零。我们假设这两种癌症的年龄特异性发病率相似;明显的差异是由于结肠癌的发展时间较长以及缺乏84岁以上人群的年龄特异性发病率数据。在这里，我们表明，一个单一的分布可以描述年龄特异性的结肠癌和睾丸癌的发病率。此外，该分布预测结肠癌的具体发病率应在90岁左右达到最大值，然后下降。从SEER和美国人口普查中获得的85-99岁妇女结肠癌发病率数据与这一预测一致。我们的结论是，睾丸癌和结肠癌的年龄特异性数据是相似的，这表明导致这两种癌症发展的潜在过程可能是相似的。
Colon cancers are thought to be an inevitable result of aging, while testicular cancers are thought to develop in only a small fraction of men, beginning in utero. These models of carcinogenesis are, in part, based upon age-specific incidence data. The specific incidence for colon cancer appears to monotonically increase with age, while that of testicular cancer increases to a maximum value at about 35 years of age, then declines to nearly zero by the age of 80. We hypothesized that the age-specific incidence for these two cancers is similar; the apparent difference is caused by a longer development time for colon cancer and the lack of age-specific incidence data for people over 84 years of age. Here we show that a single distribution can describe the age-specific incidence of both colon carcinoma and testicular cancer. Furthermore, this distribution predicts that the specific incidence of colon cancer should reach a maximum at about age 90 and then decrease. Data on the incidence of colon carcinoma for women aged 85–99, acquired from SEER and the US Census, is consistent with this prediction. We conclude that the age specific data for testicular cancers and colon cancers is similar, suggesting that the underlying process leading to the development of these two forms of cancer may be similar.
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影响因子：
30.8
作者：
Dunlop MG;Dobbins SE;Farrington SM;Jones AM;Palles C;Whiffin N;Tenesa A;Spain S;Broderick P;Ooi LY;Domingo E;Smillie C;Henrion M;Frampton M;Martin L;Grimes G;Gorman M;Semple C;Ma YP;Barclay E;Prendergast J;Cazier JB;Olver B;Penegar S;Lubbe S;Chander I;Carvajal-Carmona LG;Ballereau S;Lloyd A;Vijayakrishnan J;Zgaga L;Rudan I;Theodoratou E;Colorectal Tumour Gene Identification (CORGI) Consortium;Starr JM;Deary I;Kirac I;Kovacević D;Aaltonen LA;Renkonen-Sinisalo L;Mecklin JP;Matsuda K;Nakamura Y;Okada Y;Gallinger S;Duggan DJ;Conti D;Newcomb P;Hopper J;Jenkins MA;Schumacher F;Casey G;Easton D;Shah M;Pharoah P;Lindblom A;Liu T;Swedish Low-Risk Colorectal Cancer Study Group;Smith CG;West H;Cheadle JP;COIN Collaborative Group;Midgley R;Kerr DJ;Campbell H;Tomlinson IP;Houlston RS
通讯作者：
Houlston RS
影响因子：
64.8
作者：
Frank, SA;Nowak, MA
通讯作者：
Nowak, MA
DOI：
10.1016/j.cppeds.2011.01.001
发表时间：
2011-07
影响因子：
1.6
作者：
Calkins K;Devaskar SU
通讯作者：
Devaskar SU
影响因子：
64.8
作者：
Das, Chandrima;Lucia, M. Scott;Hansen, Kirk C.;Tyler, Jessica K.
通讯作者：
Tyler, Jessica K.
影响因子：
2.1
作者：
Arbeev, KG;Ukraintseva, SV;Yashin, AI
通讯作者：
Yashin, AI