Increased oxidative burden associated with traffic component of ambient particulate matter at roadside and urban background schools sites in London.
Increased oxidative burden associated with traffic component of ambient particulate matter at roadside and urban background schools sites in London.
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DOI：
10.1371/journal.pone.0021961
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Kelly FJ
中科院分区：
文献类型：
--
作者：
Godri KJ;Harrison RM;Evans T;Baker T;Dunster C;Mudway IS;Kelly FJ
据报道，在靠近忙碌道路的学校上学的儿童呼吸道和过敏症状的发生率增加，因此假设路边学校的PM将显示出增强的氧化电位（OP）。连续两个为期一周的空气质量监测活动进行了7所学校的采样点，反映路边和城市背景在伦敦。粒度分级颗粒物（PM）样品的化学特性与驱动合成呼吸道衬液中生物氧化反应的能力有关。相反，假设的对比，在学校网站类型之间的颗粒OP，没有强大的大小分级的OP差异，确定由于高的时间变异性的PM成分的浓度在一周的采样活动。对于通过抗坏血酸盐（OPAA m−3）和谷胱甘肽（OPGSH m−3）消耗评估的OP，每立方米空气中最高的OP是在最大尺寸的颗粒中，PM1.9-10.2。然而，当以每单位质量的颗粒表示时，OPAA µg−1没有显示出对颗粒尺寸的显著依赖性，而OPGSH µg−1有随着颗粒尺寸增加而增加的趋势，与Fe，Ba和Cu的浓度增加平行。两个OP指标彼此之间没有显著相关性，表明谷胱甘肽和抗坏血酸消耗测定响应于颗粒的不同组分。抗坏血酸消耗每单位质量没有表现出相同的依赖GSH和它是可能的，其他微量金属（锌，镍，V）或有机成分，这是富集在较细的颗粒部分，或更大的表面积的较小的颗粒，抗衡的Fe，Ba和Cu的氧化还原活性的粗颗粒。建议进一步开展长期采样和更大的分析物套件的工作，以更好地阐明氧化电位的决定因素，并更充分地探索站点类型之间的对比。
As the incidence of respiratory and allergic symptoms has been reported to be increased in children attending schools in close proximity to busy roads, it was hypothesised that PM from roadside schools would display enhanced oxidative potential (OP). Two consecutive one-week air quality monitoring campaigns were conducted at seven school sampling sites, reflecting roadside and urban background in London. Chemical characteristics of size fractionated particulate matter (PM) samples were related to the capacity to drive biological oxidation reactions in a synthetic respiratory tract lining fluid. Contrary to hypothesised contrasts in particulate OP between school site types, no robust size-fractionated differences in OP were identified due high temporal variability in concentrations of PM components over the one-week sampling campaigns. For OP assessed both by ascorbate (OPAA m−3) and glutathione (OPGSH m−3) depletion, the highest OP per cubic metre of air was in the largest size fraction, PM1.9–10.2. However, when expressed per unit mass of particles OPAA µg−1 showed no significant dependence upon particle size, while OPGSH µg−1 had a tendency to increase with increasing particle size, paralleling increased concentrations of Fe, Ba and Cu. The two OP metrics were not significantly correlated with one another, suggesting that the glutathione and ascorbate depletion assays respond to different components of the particles. Ascorbate depletion per unit mass did not show the same dependence as for GSH and it is possible that other trace metals (Zn, Ni, V) or organic components which are enriched in the finer particle fractions, or the greater surface area of smaller particles, counter-balance the redox activity of Fe, Ba and Cu in the coarse particles. Further work with longer-term sampling and a larger suite of analytes is advised in order to better elucidate the determinants of oxidative potential, and to fuller explore the contrasts between site types.
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影响因子：
3.5
作者：
Halliwell, B
通讯作者：
Halliwell, B
影响因子：
10.4
作者：
Künzli N;Mudway IS;Götschi T;Shi T;Kelly FJ;Cook S;Burney P;Forsberg B;Gauderman JW;Hazenkamp ME;Heinrich J;Jarvis D;Norbäck D;Payo-Losa F;Poli A;Sunyer J;Borm PJ
通讯作者：
Borm PJ
影响因子：
6.3
作者：
Dalsoren, S. B.;Eide, M. S.;Isaksen, I. S. A.
通讯作者：
Isaksen, I. S. A.
影响因子：
5
作者：
HUANG, XD;OLMEZ, I;GORDON, GE
通讯作者：
GORDON, GE
影响因子：
5
作者：
Harrison, RM;Smith, DJT;Castro, LM
通讯作者：
Castro, LM