Association of maternal HDL2-c concentration in the first trimester and the risk of large for gestational age birth.
Association of maternal HDL2-c concentration in the first trimester and the risk of large for gestational age birth.
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孕早期母亲 HDL2-c 浓度与大于胎龄儿出生风险的关系
DOI：
10.1186/s12944-022-01688-w
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发表时间：
2022-08-15
影响因子：
4.5
通讯作者：
Yu, Huanling
中科院分区：
文献类型：
--
作者：
Huang, Dongxu;Zhu, Haiyan;Zhu, Yandi;Dang, Qinyu;Yang, Qian;Zhang, Yadi;Cai, Xiaxia;Zhao, Xiaoyan;Liang, Ning;Wang, Hongliang;Yu, Huanling
怀孕期间母体脂质水平对胎儿发育至关重要。最近的研究表明，妊娠期高密度脂蛋白胆固醇（HDL-c）水平与出生体重呈负相关。高密度脂蛋白2胆固醇（HDL 2-c）是HDL-c的主要亚类之一，其与出生体重的关系尚不清楚。探讨妊娠早期HDL 2-c浓度与大于胎龄儿（LGA）风险的关系。本研究招募了2018年10月至2020年1月在复兴医院登记、孕期定期进行产科检查、2019年6月至2020年9月分娩的孕妇。最后，549名参与者被招募参加这项研究。于孕6 ~ 14周采集孕妇的人口学特征和静脉血，检测血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-c）、高密度脂蛋白2-c（HDL 2-c）、高密度脂蛋白3-c（HDL 3-c）、低密度脂蛋白胆固醇（LDL-c）浓度。在分娩时收集新生儿特征。采用Logistic回归模型分析妊娠早期HDL 2-c浓度与LGA发生率的关系。一个诺模图，并与一致性指数的性能进行了评价。75例母亲分娩LGA婴儿，LGA发生率为13.66%。LGA母亲的血清HDL-c和HDL 2-c浓度显著低于适合胎龄（阿加）母亲。Logistic回归模型显示，当校正年龄、孕前体重指数（BMI）和产次时，HDL 2-c浓度与LGA风险呈负相关（比值比（OR）= 0.237，95%置信区间（CI）：0.099-0.567，P = 0.001）。使用所有这些风险因素生成列线图。曲线下面积（AUC）为0.663（95%CI：0.593-0.732）。妊娠早期母体HDL 2-c浓度与LGA风险呈负相关。在线版本包含补充材料，可通过10.1186/s12944-022-01688-w获得。
Maternal lipid levels during pregnancy are critical for fetal development. Recent studies revealed that high-density lipoprotein cholesterol (HDL-c) levels during pregnancy were negatively correlated with birthweight. High-density lipoprotein 2 cholesterol (HDL2-c) is one of the major subclasses of HDL-c, and its relationship with birthweight is unclear. Association of HDL2-c concentration in the first trimester and risk of large for gestational age (LGA) was explored. This study recruited pregnant women who registered in Fuxing Hospital from October 2018 to January 2020, had regular obstetric examinations during pregnancy, and delivered between June 2019 and September 2020. Finally, 549 participants were recruited for the study. Maternal demographic characteristics and venous blood were collected at the 6th-14th gestational week, and serum total cholesterol (TC), triglyceride (TG), HDL-c, HDL2-c, high-density lipoprotein 3 cholesterol (HDL3-c), and low-density lipoprotein cholesterol (LDL-c) concentrations were detected. Neonatal characteristics were collected at delivery. A logistic regression model was used to explore the relationship between the first trimester HDL2-c concentration and LGA incidence. A nomogram was developed, and the performance was evaluated with a concordance index. Seventy-five mothers delivered LGA infants, and the LGA incidence was 13.66%. LGA mothers had significantly lower serum HDL-c and HDL2-c concentrations than appropriate for gestational age (AGA) mothers. A logistic regression model showed that HDL2-c concentration was negatively correlated with LGA risk (odds ratio (OR) = 0.237, 95% confidence intervals (CI): 0.099–0.567, P = 0.001) when adjusted for age, prepregnancy body mass index (BMI), and parity. A nomogram was generated using all these risk factors. The area under the curve (AUC) was 0.663 (95% CI: 0.593–0.732). Maternal HDL2-c concentration in the first trimester was negatively correlated with the risk of LGA. The online version contains supplementary material available at 10.1186/s12944-022-01688-w.
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影响因子：
1.7
作者：
Rincon, J. A. A.;Madeira, E. M.;Schneider, A.
通讯作者：
Schneider, A.
影响因子：
2.3
作者：
Zeljkovic, Aleksandra;Vekic, Jelena;Mikovic, Zeljko
通讯作者：
Mikovic, Zeljko
DOI：
10.1159/000014190
发表时间：
2000-01-01
期刊：
BIOLOGY OF THE NEONATE
影响因子：
--
作者：
Merzouk, H;Meghelli-Bouchenak, M;Belleville, J
通讯作者：
Belleville, J
DOI：
10.1161/atvbaha.107.145672
发表时间：
2007-08-01
影响因子：
8.7
作者：
Kontush, Anatol;Therond, Patrice;Chapman, M. John
通讯作者：
Chapman, M. John
影响因子：
2
作者：
Catov JM;Mackey RH;Scifres CM;Bertolet M;Simhan HN
通讯作者：
Simhan HN