Adiposity and breast cancer risk in postmenopausal women: Results from the UK Biobank prospective cohort.
Adiposity and breast cancer risk in postmenopausal women: Results from the UK Biobank prospective cohort.
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DOI：
10.1002/ijc.31394
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发表时间：
2018-09-01
影响因子：
6.4
通讯作者：
Reeves GK
中科院分区：
文献类型：
--
作者：
Guo W;Key TJ;Reeves GK
体型是绝经后乳腺癌的一个重要的可改变危险因素。然而，目前尚不清楚脂肪量的直接测量是否比人体测量测量更好的风险指标，或者中心性肥胖是否可能导致整体肥胖之外的风险。我们分析了英国生物银行 2006 年至 2014 年间 162,691 名绝经后女性的数据。身体尺寸由训练有素的技术人员测量。多变量调整的 Cox 回归用于估计相对风险。分析按招募时的年龄、地区和社会经济状况进行分层，并根据乳腺癌家族史、初潮年龄、第一胎年龄、产次、绝经年龄、既往激素替代疗法使用情况、吸烟、饮酒、身高、体力活动和种族进行调整。在平均 5.7 年的随访期间，我们观察到了 2,913 例侵袭性乳腺癌事件。从所有指标来看，随着肥胖的增加，绝经后乳腺癌的风险持续增加。比较身体脂肪量最高（中位数 37.6 公斤）和最低（中位数 17.6 公斤）四分位女性的点估计值为 1.70（95% 置信区间 1.52-1.90）。 BMI 和身体脂肪量的每 SD 增加与乳腺癌风险之间的关联程度相似，这表明脂肪的阻抗测量并不是比人体测量测量更好的风险指标。调整身体脂肪量后，人体测量的中心性肥胖与乳腺癌风险之间的关联减弱。从所有肥胖指标来看，绝经后 12 年或以上的女性的风险程度更大。 什么是新的？ 肥胖与绝经后乳腺癌的风险增加有关。然而，使用生物电阻抗测量对脂肪量进行直接分析是否比体重指数（BMI）和腰围等人体测量测量更好地指示乳腺癌风险，目前尚不清楚。在这项研究中，基于从英国生物银行获得的绝经后妇女的数据，作者发现体重指数、腰围和脂肪的直接生物阻抗测量显示出与绝经后乳腺癌风险同样强烈的相关性。调整全身脂肪量后，中心性肥胖不再与乳腺癌风险相关。
Body size is an important modifiable risk factor for postmenopausal breast cancer. However, it remains unclear whether direct measures of fat mass are better indicators of risk than anthropometric measures, or whether central adiposity may contribute to risk beyond overall adiposity. We analyzed data from 162,691 postmenopausal women in UK Biobank followed from 2006 to 2014. Body size was measured by trained technicians. Multivariable‐adjusted Cox regression was used to estimate relative risks. Analyses were stratified by age at recruitment, region and socioeconomic status, and adjusted for family history of breast cancer, age at menarche, age at first birth, parity, age at menopause, previous hormone replacement therapy use, smoking, alcohol intake, height, physical activity and ethnicity. We observed 2,913 incident invasive breast cancers during a mean 5.7 years of follow‐up. There was a continuous increase in risk of postmenopausal breast cancer with increasing adiposity, across all measures. The point estimate, comparing women in the top (median 37.6 kg) to bottom (median 17.6 kg) quartile of body fat mass was 1.70 (95% confidence interval 1.52–1.90). The magnitudes of the associations between per SD increase in BMI and body fat mass with breast cancer risk were similar, suggesting impedance measures of fat were not substantially better indicators of risk than anthropometric measures. After adjusting for body fat mass, the associations between anthropometric measures of central adiposity and breast cancer risk were attenuated. The magnitude of risk, across all measures of adiposity, was greater in women who had been postmenopausal for 12 or more years. What's new? Obesity is associated with an increased risk of postmenopausal breast cancer. However, whether direct anaylses of fat mass using bioelectrical impedance measures are better indicators of breast cancer risk than anthropometric measures, such as body mass index (BMI) and waist circumference, remains unclear. In this study, based on data for postmenopausal women obtained from UK Biobank, the authors found that BMI, waist circumference, and direct bioimpedance measures of fat showed similarly strong associations with postmenopausal breast cancer risk. Central adiposity was no longer associated with breast cancer risk after adjusting for overall body fat mass.
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影响因子：
8.8
作者：
Moller, H.;Richards, S.;Hanchett, N.;Riaz, S. P.;Luechtenborg, M.;Holmberg, L.;Robinson, D.
通讯作者：
Robinson, D.
影响因子：
7.1
作者：
LUKASKI, HC;JOHNSON, PE;LYKKEN, GI
通讯作者：
LYKKEN, GI
影响因子：
2.3
作者：
Gaudet, Mia M.;Carter, Brian D.;Gapstur, Susan M.
通讯作者：
Gapstur, Susan M.
影响因子：
--
作者：
Amadou A;Hainaut P;Romieu I
通讯作者：
Romieu I
影响因子：
4.7
作者：
Bohm, A.;Heitmann, B. L.
通讯作者：
Heitmann, B. L.